Evidence map›Paper›PMID 37513473›Full record

ArticleMolecules (Basel, Switzerland)2023

Modification of the 4-Hydroxyphenylacetate-3-hydroxylase Substrate Pocket to Increase Activity towards Resveratrol.

Qianchao Zhang, Yuning Jin, Kai Yang, Sheng Hu, Changjiang Lv, Jun Huang, Jiaqi Mei, Weirui Zhao, Lehe Mei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Qianchao ZhangCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Yuning JinSchool of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China.
Kai YangDepartment of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Sheng HuSchool of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China.
Changjiang LvSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Jun HuangSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Jiaqi MeiHangzhou Huadong Medicine Group Co., Ltd., Hangzhou 310011, China.
Weirui ZhaoSchool of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China.
Lehe MeiSchool of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China.
Ningbo University of Technology · CNZhejiang University · CNZhejiang University of Science and Technology · CN

Funding

National Natural Science Foundation of China 32071268, 31971372Zhejiang Natural Science Foundation LY21B060003, LY23B060001
6 · The paper itself

Abstract

4-Hydroxyphenylacetate-3-hydroxylase (4HPA3H; EC 1.14.14.9) is a heterodimeric flavin-dependent monooxygenase complex that catalyzes the

Indexed as

Mixed Function OxygenasesStilbenesPhenylacetatesResveratrol3,3',4,5'-tetrahydroxystilbene4-hydroxyphenylacetateMixed Function OxygenasesPhenylacetatesResveratrolStilbenes4-hydroxyphenylacetate-3-hydroxylaseortho-hydroxylationpiceatannolsemi-rational designsubstrate pocket

Identifiers

PMID37513473
PMCPMC10384689
OpenAlexW4385226381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.