Evidence map›Paper›PMID 37513464›Full record

ArticleMolecules (Basel, Switzerland)2023

Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease.

Euitaek Yang, Junwei Wang, Lauren N Woodie, Michael W Greene, Amal Kaddoumi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Euitaek YangDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, 720 S Donahue Dr., Auburn, AL 36849, USA.
Junwei WangDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, 720 S Donahue Dr., Auburn, AL 36849, USA.
Lauren N WoodieDepartment of Nutrition, College of Human Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-2427-4586
Michael W GreeneDepartment of Nutrition, College of Human Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-6443-8269
Amal KaddoumiDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, 720 S Donahue Dr., Auburn, AL 36849, USA.ORCID 0000-0001-9792-7766
Auburn University · US

Funding

Olive-derived oleocanthal as a novel natural product molecule to restore cerebrovascular function and integrity in a CAA mouse modelR21NS101506 · NINDS · AUBURN UNIVERSITY AT AUBURN · PI KHALIL KADDOUMI, AMAL F, PANIZZI, PETER ROLF · 2017 to 2018
$401k
Evaluation of oral oleocanthal to prevent and/or treat Alzheimer’s disease and related dementiasR43AG061952 · NIA · OLEOLIVE, INC. · PI CARDELLI, JAMES · 2018 to 2019
$337k
NIA NIH HHS R43 AG061952NIA NIH HHS R43AG061952NINDS NIH HHS R21 NS101506NINDS NIH HHS R21NS101506
6 · The paper itself

Abstract

Aging is a major risk factor for Alzheimer's disease (AD). AD mouse models are frequently used to assess pathology, behavior, and memory in AD research. While the pathological characteristics of AD are well established, our understanding of the changes in the metabolic phenotypes with age and pathology is limited. In this work, we used the Promethion cage systems

Indexed as

Alzheimer DiseaseAldehydesAmyloid beta-PeptidesAnimalsBrainCyclopentane MonoterpenesDisease Models, AnimalMiceMice, TransgenicPhenolsPhenotypeAldehydesAmyloid beta-PeptidesCyclopentane MonoterpenesoleocanthalPhenolsAlzheimer’s diseaseblood–brain barriermetabolic phenotypeoleocanthalPromethion cagessleep behavior

Identifiers

PMID37513464
PMCPMC10385639
OpenAlexW4385172505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.