UPLC-MS/MS Method for Simultaneous Determination of Valnemulin and Its Metabolites in Crucian Carp: In Vivo Metabolism and Tissue Distribution Analyses.

Qiyu Yang, Xiaojun Zhang, Qianfeng Wang, Yaqian Zhong, Wenjing Liu

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qiyu YangSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.

Xiaojun ZhangKey Lab of Mariculture and Enhancement of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, China.

Qianfeng WangSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.

Yaqian ZhongSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.

Wenjing LiuSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.

Zhejiang Ocean University · CNZhejiang Marine Fisheries Research Institute · CN

Funding

the Special projects of research institutes in Zhejiang Province HYS-CZ-202310

6 · The paper itself

Abstract

Valnemulin (VML) is a semi-synthetic pleuromutilin derivative widely used to treat animal bacterial diseases. However, no study has comprehensively evaluated VML metabolism in aquatic animals, including crucian carp. This study aimed to investigate VML metabolism in crucian carp. VML metabolites in crucian carp were quantified via intraperitoneal injection and analyzed via ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Three VML metabolites were detected in crucian carp via ultra-performance liquid chromatography-tandem quadrupole and time-of-flight mass spectrometry (UPLC-Q-TOF/MS) structural analysis. The enrichment and metabolism rules of the metabolites were summarized based on tissue distribution and concentration changes of the three metabolites. The metabolites were mainly found in the liver at 0.1 h after VML injection. The levels of the metabolites were abundant in the bile from 4 h to 12 h and in the skin after 72 h. The levels of the metabolites in the bile first increased, then decreased. The metabolism in the liver was completed at 72 h. The metabolites were detected in the skin following a 72 h period, which increased with time.

Indexed as

CarpsAnimalsChromatography, High Pressure LiquidChromatography, LiquidDiterpenesTandem Mass SpectrometryTissue DistributionDiterpenesvalnemulincrucian carpdetectionmetabolitesvalnemulin

Identifiers

PMID37513305

DOI10.3390/molecules28145430

PMCPMC10383100

OpenAlexW4384525870

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.