Evidence map›Paper›PMID 37513226›Full record

ReviewMolecules (Basel, Switzerland)2023

The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.

Yudong Sun, Xiaoqiang Huang, Yoichi Osawa, Yuqing Eugene Chen, Haoming Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. P450 Fusion Protein Expressed inMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yudong SunDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Xiaoqiang HuangDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1005-848X
Yoichi OsawaDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Yuqing Eugene ChenDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Haoming ZhangDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8765-4394
University of Michigan · US

Funding

P450 and NO Synthase Regulation by Multiprotein ComplexesR01GM077430 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OSAWA, YOICHI, ZHANG, HAOMING · 2006 to 2022
$6.5M
IDOL and dyslipidemia in cardiovascular diseasesR01HL147527 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2019 to 2022
$3.1M
Development of gene editing based therapy for cardiovascular diseasesR01HL159900 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE, HAN, RENZHI · 2021 to 2024
$2.8M
Browning of perivascular adipose tissue protects against thoracic aortic aneurysmR01HL159871 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2022 to 2025
$2.3M
Structural basis for detoxification of environmental pollutants by native complexes of CYP2B family with its redox partnersR21ES030791 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SU, MIN, ZHANG, HAOMING · 2020 to 2021
$429k
Structure-based computational engineering of saCas9 PAM requirementR41GM149016 · NIGMS · ATGC, INC. · PI HUANG, XIAOQIANG, XIA, XIAOFENG · 2023 to 2023
$275k
NHLBI NIH HHS R01 HL147527NHLBI NIH HHS R01 HL159871NHLBI NIH HHS R01 HL159900NIEHS NIH HHS R21 ES030791NIGMS NIH HHS R01 GM077430NIGMS NIH HHS R41 GM149016NIH HHS ES030791NIH HHS GM077430NIH HHS GM149016NIH HHS HL147527NIH HHS HL159871NIH HHS HL159900
6 · The paper itself

Abstract

Wild-type cytochrome P450 CYP102A1 from

Indexed as

Bacillus megateriumNADPH-Ferrihemoprotein ReductaseBacterial ProteinsCytochrome P-450 Enzyme SystemElectron TransportOxidation-ReductionBacterial ProteinsCytochrome P-450 Enzyme SystemNADPH-Ferrihemoprotein Reductasecomputational protein designCYP102A1directed evolutionmachine learning

Identifiers

PMID37513226
PMCPMC10383305
OpenAlexW4384203069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.