ArticleMolecules (Basel, Switzerland)2023
Methodological Aspects of Green Extraction of Usnic Acid Using Natural Deep Eutectic Solvents.
Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Applications of (+) Usnic Acid Modulate Antioxidant Enzymatic Activity in Strawberry Plants.Molecules (Basel, Switzerland) · 2026Article
- Volatile Natural Deep Eutectic Solvents (VNADESs) for Extraction of Shikonin Derivatives fromMolecules (Basel, Switzerland) · 2026Article
- Evaluation of the Antioxidant and Antimicrobial Activity of Natural Deep Eutectic Solvents (NADESs) Based on Primary and Specialized Plant Metabolites.Molecules (Basel, Switzerland) · 2025Article
- From Mushrooms to Molecules: Exploring Depsidones inMolecules (Basel, Switzerland) · 2025Article
- Extraction of lichen bioactive compounds using volatile natural deep eutectic solvents and comparative analytical approaches.Scientific reports · 2025Article
- Green Extraction of Depsidones and Depsides fromInternational journal of molecular sciences · 2024Article
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Authors and funding
5 authors.
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Abstract
Usnic acid (UA) is a compound with multiple biological activities that make it useful in various industries, e.g., pharmaceutical, cosmetic, dentistry, and agricultural sectors. Lichens are the primary source of UA, which is primarily extracted using acetone. This study aimed to investigate the solubility of UA in numerous natural deep eutectic solvents (NADESs) and use a mixture of thymol and camphor as a NADES in the optimization of the UA extraction process with the design of experiments method. For numerical optimization, the following parameters were employed in the experiment to confirm the model: a camphor-to-thymol ratio of 0.3, a liquid-to-solid ratio of 60, and a time of 30 min. The obtained experimental results aligned well with the predicted values, with the mean experimental value falling within the confidence interval, exhibiting deviations between 11.93 and 14.96. By employing this model, we were able to optimize the extraction procedure, facilitating the isolation of approximately 91% of the total UA content through a single extraction, whereas a single acetone extraction yielded only 78.4% of UA.
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