Evidence map›Paper›PMID 37512950›Full record

ReviewMicroorganisms2023

The Potential Role of Gut Bacteriome Dysbiosis as a Leading Cause of Periprosthetic Infection: A Comprehensive Literature Review.

Konstantinos Valtetsiotis, Alberto Di Martino, Matteo Brunello, Leonardo Tassinari, Claudio D'Agostino, Francesco Traina, Cesare Faldini

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07651462 (Preoperative Metabolic Optimization), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07651462 narecruitingnot on this mapstarted 2025, after this paper: background citation

Preoperative Metabolic Optimization: Influence of Intermittent and Buchinger-Type Fasting on the Gut Microbiome, Immune Profile, and Postoperative Complications in Patients Undergoing Primary Total Hip Arthroplasty - A Randomized Controlled Trial

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2025 to 2026Enrolled130ConditionsHip Osteoarthritis, Arthroplasty, Replacement, Hip, Postoperative Complications, Surgical Wound InfectionArmsBuchinger Fastenbox + intermittent fasting (20-day preoperative schedule)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Konstantinos ValtetsiotisDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.
Alberto Di MartinoDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0002-0716-4951
Matteo BrunelloDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0001-9376-5480
Leonardo TassinariDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0003-3834-6798
Claudio D'AgostinoDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.
Francesco TrainaDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0002-0196-101X
Cesare FaldiniDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.
Istituto Ortopedico Rizzoli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Periprosthetic joint infections (PJIs) represent a small yet important risk when undertaking a joint arthroplasty; they occur in approximately 1-2% of treatments. These infections create a medical and financial burden for patients and healthcare systems. Despite the introduction of recognized best clinical practices during arthroplasty operations, it is not yet possible to further reduce the risk of infection after surgery. The purpose of this review is to raise awareness of the potential role of gut dysbiosis in the development of PJIs and to highlight the potential of the gut bacteriome as a possible target for preventing them. (2) Methods: We compiled all the available data from five databases, examining the effects of gut dysbiosis in human and murine studies, following PRISMA guidelines, for a total of five reviewed studies. (3) Results: One human and one murine study found the Trojan horse theory applicable. Additionally, inflammatory bowel diseases, gut permeability, and oral antibiotic ingestion all appeared to play a role in promoting gut dysbiosis to cause PJIs, according to the other three studies. (4) Conclusions: Gut dysbiosis is linked to an increased risk of PJI.

Indexed as

Crohn’s diseasedysbiosisgutIBDinfectionjointmicrobiotaperiprosthetic joint infectiontotal hip arthroplastytotal knee arthroplasty

Identifiers

PMID37512950
PMCPMC10385477
OpenAlexW4383724545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.