Evidence map›Paper›PMID 37512936›Full record

ArticleMicroorganisms2023

Influence of Varying Pre-Culture Conditions on the Level of Population Heterogeneity in Batch Cultures with an

Manh Dat Hoang, Sophi Riessner, Jose Enrique Oropeza Vargas, Nikolas von den Eichen, Anna-Lena Heins

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Robustness of theBioengineering (Basel, Switzerland) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Manh Dat HoangChair of Biochemical Engineering, TUM School of Engineering and Design, Technical University of Munich, 85748 Garching, Germany.ORCID 0000-0002-2863-7826
Sophi RiessnerChair of Biochemical Engineering, TUM School of Engineering and Design, Technical University of Munich, 85748 Garching, Germany.
Jose Enrique Oropeza VargasChair of Biochemical Engineering, TUM School of Engineering and Design, Technical University of Munich, 85748 Garching, Germany.
Nikolas von den EichenChair of Biochemical Engineering, TUM School of Engineering and Design, Technical University of Munich, 85748 Garching, Germany.
Anna-Lena HeinsChair of Biochemical Engineering, TUM School of Engineering and Design, Technical University of Munich, 85748 Garching, Germany.
Technical University of Munich · DE

Funding

Deutsche Forschungsgemeinschaft HE8502/1-1Federal Ministry of Education and Research 031B0463B
6 · The paper itself

Abstract

When targeting robust, high-yielding bioprocesses, phenomena such as population heterogeneity have to be considered. Therefore, the influence of the conditions which the cells experience prior to the main culture should also be evaluated. Here, the influence of a pre-culture medium (complex vs. minimal medium), optical density for inoculation of the main culture (0.005, 0.02 and 0.0125) and harvest time points of the pre-culture in exponential growth phase (early, mid and late) on the level of population heterogeneity in batch cultures of the

Indexed as

batch culturepopulation heterogeneitypre-cultureprincipal component analysistriple reporter strain

Identifiers

PMID37512936
PMCPMC10384452
OpenAlexW4383552842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.