Evidence map›Paper›PMID 37512872›Full record

ArticleMicroorganisms2023

Characterisation of Mid-Gestation Amniotic Fluid Cytokine and Bacterial DNA Profiles in Relation to Pregnancy Outcome in a Small Australian Cohort.

Lisa F Stinson, Yey Berman, Shaofu Li, Jeffrey A Keelan, Jan E Dickinson, Dorota A Doherty, John P Newnham, Matthew S Payne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lisa F StinsonSchool of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-2799-2727
Yey BermanDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6008, Australia.ORCID 0000-0002-5632-2602
Shaofu LiDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6008, Australia.
Jeffrey A KeelanSchool of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-5403-6266
Jan E DickinsonDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6008, Australia.
Dorota A DohertyDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6008, Australia.ORCID 0000-0002-5507-9065
John P NewnhamDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6008, Australia.
Matthew S PayneDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, WA 6008, Australia.ORCID 0000-0002-2308-3561
The University of Western Australia · AU

Funding

Channel 7 Telethon Trust N/ANational Health and Medical Research Council 1010315Women and Infants Research Foundation N/A
6 · The paper itself

Abstract

A well-established association exists between intrauterine bacteria and preterm birth. This study aimed to explore this further through documenting bacterial and cytokine profiles in Australian mid-gestation amniotic fluid samples from preterm and term births. Samples were collected during amniocenteses. DNA was extracted and the full-length 16S rRNA gene was amplified and sequenced. Levels of the cytokines IL-1β, IL-6, IL-10, TNF-α and MCP-1 were determined using the Milliplex MAGPIX system. Bacterial DNA profiles were low in diversity and richness, with no significant differences observed between term and preterm samples. No differences in the relative abundance of individual OTUs between samples were identified. IL-1β and TNF-α levels were significantly higher in samples containing reads mapping to

Indexed as

amniotic fluidbacteriacytokinesinflammationmicrobiomePCR (polymerase chain reaction)preterm birth

Identifiers

PMID37512872
PMCPMC10384451
OpenAlexW4382787008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.