Evidence map›Paper›PMID 37512861›Full record

ReviewMicroorganisms2023

Quorum Sensing in Oral Biofilms: Influence on Host Cells.

Malee Nagi, Iain L C Chapple, Praveen Sharma, Sarah A Kuehne, Josefine Hirschfeld

Abstract readReview
In one paragraph

Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. [Research Progress on Quorum Sensing-Regulated Oral Microbial Interaction Networks in Periodontitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Streptococcal peptides and their roles in host-microbe interactions.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Malee NagiOral Microbiology Group, School of Dentistry, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, UK.ORCID 0000-0003-3065-3195
Iain L C ChapplePeriodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, UK.
Praveen SharmaPeriodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, UK.
Sarah A KuehneOral Microbiology Group, School of Dentistry, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, UK.ORCID 0000-0001-6790-8433
Josefine HirschfeldPeriodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, UK.

Funding

Biotechnology and Biological Sciences Research Council GSK Ref BIDS Rec: 100708
6 · The paper itself

Abstract

Quorum sensing molecules (QSMs) in the oral cavity regulate biofilm formation, the acquisition of iron, stress responses, and the expression of virulence factors. However, knowledge of the direct QSM-host interactions in the oral environment is limited, although their understanding could provide greater insight into the cross-kingdom communication occurring during oral disease development. This review aims to explore the literature on oral QSM-host interactions and to highlight areas of advancement in this field. The studies included in this review encompass an array of cell types and oral QSMs, with particular emphasis on immune cells and their relationship to periodontal diseases. It can be inferred from the current literature that QSMs are utilised by host cells to detect bacterial presence and, in the majority of cases, elicit an immune response towards the environmental QSMs. This may provide a base to target QSMs as a novel treatment of oral diseases. However,

Indexed as

autoinducer-2 (AI-2)N-acyl homoserine lactones (AHL)oral biofilmperiodontal diseasesquorum sensing

Identifiers

PMID37512861
PMCPMC10386421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.