Evidence map›Paper›PMID 37512822›Full record

ArticleMicroorganisms2023

Francesco Di Pierro, Ilenia Campedelli, Patrick De Marta, Fabio Fracchetti, Antonio Del Casale, Ilaria Cavecchia, Mariarosaria Matera, Massimiliano Cazzaniga, Alexander Bertuccioli, Luigina Guasti and 1 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06850714 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Use of Bifidobacterium Breve PRL2020 in Preventing Side Effects From Amoxicillin or Amoxicillin/Clavulanic Acid Antibiotic Use: A Randomized Controlled Trial

TypeinterventionalSponsorLiaquat University of Medical & Health SciencesRan2025 to 2025Enrolled800ConditionsAntibiotic Side EffectArmsBifidobacterium breve PRL2020 (Brevicillin®), Amoxicillin or Amoxicillin/Clavulanic Acid
NCT07234448 nacompletednot on this mapstarted 2025, after this paper: background citation

Evaluation of the Use of a Probiotic Containing Bifidobacterium Breve PRL2020 in Oral Drops in Preventing Side Effects From Amoxicillin or Amoxicillin/Clavulanic Acid Antibiotic Use: a Multicentre, Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial

TypeinterventionalSponsorLiaquat University of Medical & Health SciencesRan2025 to 2026Enrolled1,100ConditionsAntibiotic-associated DiarrheaArmsBrevicillin® gocce (Bifidobacterium breve PRL2020), Placebo (matching oil drops)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Metabolic Engineering of ProbioticFoods (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Role ofFrontiers in pediatrics · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Isolation and Characterisation ofFoods (Basel, Switzerland) · 2024
    Article
  11. Genome analysis ofFrontiers in microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Francesco Di PierroScientific & Research Department, Velleja Research, 20125 Milan, Italy.ORCID 0000-0001-6654-8675
Ilenia CampedelliMicrobion, San Giovanni Lupatoto, 37057 Verona, Italy.
Patrick De MartaMicrobion, San Giovanni Lupatoto, 37057 Verona, Italy.
Fabio FracchettiMicrobion, San Giovanni Lupatoto, 37057 Verona, Italy.
Antonio Del CasaleMicrobion, San Giovanni Lupatoto, 37057 Verona, Italy.
Ilaria CavecchiaMicrobiomic Department, Koelliker Hospital, 10134 Turin, Italy.
Mariarosaria MateraDepartment of Pediatric Emergencies, Misericordia Hospital, 58100 Grosseto, Italy.
Massimiliano CazzanigaScientific & Research Department, Velleja Research, 20125 Milan, Italy.
Alexander BertuccioliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61122 Urbino, Italy.ORCID 0000-0002-3922-9115
Luigina GuastiDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Nicola ZerbinatiDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Nuovo Ospedale San Giovanni di Dio · ITUniversity of Insubria · ITOspedale Koelliker · ITOspedale Misericordia - Grosseto · ITUniversity of Urbino · ITVelleja Research · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotics are one of the greatest scientific achievements of modern medicine, but excessive use is creating challenges for the future of medicine. Antibiotic resistance (AR) is thought to cause changes in bowel habits and an increased risk of gastroenteritis, but it may also increase the risk of overweight, obesity, autoimmune and atopic diseases, and a low response to vaccines and cancer, likely mediated by antibiotic-induced gut dysbiosis. Probiotic add-on therapy could partially prevent antibiotic-induced gut dysbiosis, but their antibiotic sensitivity features likely limits this potential. The EFSA (European Food Safety Authority) guidelines consider the use of probiotics whose antibiotic-resistant profile could be transferable an important hazard. Recently, a strain of

Indexed as

amoxicillinampicillinclavulanic aciderythromycinLMG S-32458microbiotaprobioticsrifaximin

Identifiers

PMID37512822
PMCPMC10383950
OpenAlexW4382138094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.