ReviewMicroorganisms2023
Unveiling the Enigmatic Adenoids and Tonsils: Exploring Immunology, Physiology, Microbiome Dynamics, and the Transformative Power of Surgery.
Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Short-Term Weight Gain after Tonsillectomy Does Not Lead to Overweight: A Systematic Review.Nutrients · 2024Pooled it
- Dentofacial Orthopedic Treatment vs. Adenotonsillectomy in Children with Mild to Moderate OSA and Mandibular Retrognathia: A Randomized Controlled Trial.Dentistry journal · 2026Article
- Nasal Irrigation in Children: From Pathophysiological Rationale to Clinical Practice.Children (Basel, Switzerland) · 2026Review
- Article
- Peritonsillar abscess in children: age-stratified incidence rates, microbiology, and evaluation of penicillin as drug of choice.Annals of clinical microbiology and antimicrobials · 2026Article
- Association between childhood tonsillectomy and increased risk of autoimmune disease: a nationwide population-based cohort study.Frontiers in medicine · 2026Article
- Morphometric and immunohistochemical reorganisation of the palatine tonsil in chronic tonsillitis and its response to combined ozone-ultrasound therapy.Frontiers in surgery · 2026Article
- Nasopharyngeal swab transcriptomics identifies divergent molecular signatures in adenoid hypertrophy and allergic rhinitis comorbidity.Frontiers in immunology · 2026Article
- Efficacy comparison between dentofacial orthopedic treatment and adenotonsillectomy on children with obstructive sleep apnea and skeletal class II malocclusion: a retrospective study.BMC oral health · 2025Article
- Serum CXCL-1 as a predictive biomarker for glucocorticoid resistance in adenoids of patients with adenoid hypertrophy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Mendelian randomization analysis reveals causal relationship between tonsillectomy and irritable bowel syndrome.Frontiers in surgery · 2025Article
- Article
- New ways of thinking for sustainable oral health: how integrating oral, respiratory, and postural health into early childhood development can drive innovation and research.Frontiers in dental medicine · 2025Article
- The hyoid bone position and upper airway morphology among children with and without adenotonsillar hypertrophy: a cross-sectional study.BMC oral health · 2024Article
- Comparing the Microbiome of the Adenoids in Children with Secretory Otitis Media and Children without Middle Ear Effusion.Microorganisms · 2024Article
- Changes in monocyte subsets in volunteers who received an oral wild-typeFrontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the intricate realm of the mucosal immune system resides a captivating duo: the adenoids (or pharyngeal tonsils) and the tonsils (including palatine, tubal, and lingual variations), which harmoniously form the Waldeyer's ring. As they are strategically positioned at the crossroads of the respiratory and gastrointestinal systems, these exceptional structures fulfill a vital purpose. They function as formidable "gatekeepers" by screening microorganisms-both bacteria and viruses-with the mission to vanquish local pathogens via antibody production. However, under specific circumstances, their function can take an unsettling turn, inadvertently transforming them into reservoirs for pathogen incubation. In this review, we embark on a fascinating journey to illuminate the distinctive role of these entities, focusing on the local immune system inside their tissues. We delve into their behavior during inflammation processes, meticulously scrutinize the indications for surgical intervention, and investigate the metamorphosis of their microbiota in healthy and diseased states. We explore the alterations that occur prior to and following procedures like adenoidectomy, tonsillectomy, or their combined counterparts, particularly in pediatric patients. By comprehending a wealth of data, we may unlock the key to the enhanced management of patients with otorhinolaryngological disorders. Empowered with this knowledge, we can embrace improved therapeutic approaches and targeted interventions/surgeries guided by evidence-based guidelines and indications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.