Evidence map›Paper›PMID 37512693›Full record

ArticleMicromachines2023

Synthesis and Characterization of Ciprofloxacin Loaded Star-Shaped Polycaprolactone-Polyethylene Glycol Hydrogels for Oral Delivery.

Wan Khartini Wan Abdul Khodir, Mohamad Wafiuddin Ismail, Shafida Abd Hamid, Rusli Daik, Deny Susanti, Muhammad Taher, Vincenzo Guarino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wan Khartini Wan Abdul KhodirDepartment of Chemistry, Kulliyyah of Science, International Islamic University Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.ORCID 0000-0002-7854-3334
Mohamad Wafiuddin IsmailDepartment of Chemistry, Kulliyyah of Science, International Islamic University Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.ORCID 0000-0003-1686-9301
Shafida Abd HamidDepartment of Chemistry, Kulliyyah of Science, International Islamic University Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.
Rusli DaikDepartment of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.ORCID 0000-0003-2426-2921
Deny SusantiDepartment of Chemistry, Kulliyyah of Science, International Islamic University Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.ORCID 0000-0002-5345-1150
Muhammad TaherDepartment of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.ORCID 0000-0002-1463-3090
Vincenzo GuarinoInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra d'Oltremare Pad.20, V.le J.F.Kennedy 54, 80125 Naples, Italy.ORCID 0000-0003-1546-3721

Funding

Ministry of Higher Education, for Fundamental Research Grant Scheme FRGS/1/2019/STG07/UIAM/02/2
6 · The paper itself

Abstract

The administration of poorly water-soluble drugs represents a relevant problem due to the low body fluids transport efficiency through hydrophilic hydrogels. Star-shaped co-polymers, i.e., amphiphilic polymers such as those with a hydrophobic core and a hydrophilic outer shell, can be used to improve weak interactions with drugs, with relevant benefits in terms of administration and controlled delivery. In this work, two different co-polymers, four-arm star-shaped PCL-PEG and six-arm star-shaped PCL-PEG, were synthesized via ring-opening polymerization to be loaded with ciprofloxacin.

Indexed as

ciprofloxacindrug deliveryhydrogelsPCL armsstar co-polymers

Identifiers

PMID37512693
PMCPMC10383659

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.