Synthesis and Characterization of β-Cyclodextrin-Hybridized Exfoliated Kaolinite Single Nanosheets as Potential Carriers of Oxaliplatin with Enhanced Loading, Release, and Cytotoxic Properties.

Mashael D Alqahtani, Nourhan Nasser, May N Bin Jumah, Saleha A AlZahrani, Ahmed A Allam, Mostafa R Abukhadra, Stefano Bellucci

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Article in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Mashael D AlqahtaniDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.

Nourhan NasserGeology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt.

May N Bin JumahDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.

Saleha A AlZahraniDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.

Ahmed A AllamZoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt.

Mostafa R AbukhadraGeology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt.ORCID 0000-0001-5404-7996

Stefano BellucciINFN-Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy.ORCID 0000-0003-0326-6368

Funding

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6 · The paper itself

Abstract

Natural kaolinite was subjected to a successful exfoliation process into separated kaolinite nanosheets (KNs), followed by hybridization with β-cyclodextrin biopolymer (β-CD), forming an advanced bio-nanocomposite (β-CD/KNs). The synthetic products were evaluated as enhanced delivery structures for oxaliplatin chemotherapy (OXAPN). The hybridization of KNs with β-CD polymer notably enhanced the loading capacity to 355.3 mg/g (β-CD/KNs) as compared to 304.9 mg/g for KNs. The loading of OXAPN into both KNs and β-CD/KNs displayed traditional pseudo-first-order kinetics (R

Indexed as

cytotoxicityexfoliationkaoliniteloadingoxaliplatinβ-cyclodextrin

Identifiers

PMID37512232

DOI10.3390/ma16144958

PMCPMC10381760

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