Evidence map›Paper›PMID 37512162›Full record

ArticleMedicina (Kaunas, Lithuania)2023

SIRT1/Nrf2/NF-κB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage.

Manea A I Alqrad, Dina S El-Agamy, Sabrin R M Ibrahim, Alaa Sirwi, Hossam M Abdallah, Essam Abdel-Sattar, Ali M El-Halawany, Wael M Elsaed, Gamal A Mohamed

Open access · goldAbstract read
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Oxidative Stress andInternational journal of molecular sciences · 2026
    Review
  4. Life (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Phytochemical Profiling and Biological Evaluation ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. Oleanolic acid enhanced the anticancer effect of fluorouracil by regulating Ca2+ levels in hepatocellular carcinoma cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Manea A I AlqradDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Dina S El-AgamyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-7545-6235
Sabrin R M IbrahimDepartment of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.ORCID 0000-0002-6858-7560
Alaa SirwiDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-7823-1210
Hossam M AbdallahDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0234-7492
Essam Abdel-SattarDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza 12613, Egypt.ORCID 0000-0002-0617-1420
Ali M El-HalawanyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza 12613, Egypt.ORCID 0000-0002-5864-1674
Wael M ElsaedDepartment of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Gamal A MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-2971-6008
King Abdulaziz University · SACairo University · EGMansoura University · EGBatterjee Medical College

Funding

The Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia has funded this project, under grant no. (KEP-MSc: 27-166-1443). KEP-MSc: 27-166-1443
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NF-kappa BOleanolic AcidAnimalsAnti-Inflammatory AgentsAntioxidantsMiceNF-E2-Related Factor 2Oxidative StressSignal TransductionSirtuin 1Tumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsNF-E2-Related Factor 2NF-kappa BOleanolic AcidSirtuin 1Tumor Necrosis Factor-alphaBax/Bcl-2drug discoveryhealth and wellbeinghepatorenal damageoleanolic acidSIRT1/Nrf2/NF-κBthioacetamideViscum schimperi

Identifiers

PMID37512162
PMCPMC10383078
OpenAlexW4385225498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.