Evidence map›Paper›PMID 37511940›Full record

ArticleLife (Basel, Switzerland)2023

Transcutaneous Spinal Cord Stimulation Facilitates Respiratory Functional Performance in Patients with Post-Acute COVID-19.

Alexander Ovechkin, Tatiana Moshonkina, Natalia Shandybina, Vsevolod Lyakhovetskii, Ruslan Gorodnichev, Sergey Moiseev, Ricardo Siu, Yury Gerasimenko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexander OvechkinKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-8067-7630
Tatiana MoshonkinaPavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg, Russia.ORCID 0000-0002-8934-5253
Natalia ShandybinaPavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg, Russia.ORCID 0000-0001-8332-1843
Vsevolod LyakhovetskiiPavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg, Russia.ORCID 0000-0001-5948-0991
Ruslan GorodnichevVelikie Luki State Academy of Physical Education and Sports, 182100 Velikie Luki, Russia.
Sergey MoiseevVelikie Luki State Academy of Physical Education and Sports, 182100 Velikie Luki, Russia.
Ricardo SiuKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-3302-5496
Yury GerasimenkoKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40202, USA.
Pavlov Institute of Physiology of the Russian Academy of Sciences · RUUniversity of Louisville · USVelikie Luki State Academy of Physical Culture and Sports · RU

Funding

Epidural spinal cord stimulation and respiratory motor function after injuryR01HL150581 · NHLBI · UNIVERSITY OF LOUISVILLE · PI OVECHKIN, ALEXANDER VLADIMIROVICH · 2021 to 2025
$3.7M
Transformation of Paraplegic Paralysis to Overground Stepping in HumansR01NS102920 · NINDS · UNIVERSITY OF LOUISVILLE · PI OVECHKIN, ALEXANDER VLADIMIROVICH · 2019 to 2023
$2.8M
Neuromodulatory rehabilitation for respiratory motor function in individuals with chronic spinal cord injuryR01HL168294 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Alexander Vladimirovich Ovechkin · 2023 to 2026
$1.9M
NHLBI NIH HHS R01 HL150581NHLBI NIH HHS R01 HL168294NIH HHS R01HL168294NIH HHS R01NS102920
6 · The paper itself

Abstract

backgroundA growing number of studies have reported Coronavirus disease (COVID-19) related to both respiratory and central nervous system dysfunctions. This study evaluates the neuromodulatory effects of spinal cord transcutaneous stimulation (scTS) on the respiratory functional state in healthy controls and patients with post-COVID-19 respiratory deficits as a step toward the development of a rehabilitation strategy for these patients.

methodsIn this before-after, interventional, case-controlled clinical study, ten individuals with post-acute COVID-19 respiratory deficits and eight healthy controls received a single twenty-minute-long session of modulated monophasic scTS delivered over the T5 and T10 spinal cord segments. Forced vital capacity (FVC), peak forced inspiratory flow (PIF), peak expiratory flow (PEF), time-to-peak of inspiratory flow (tPIF), and time-to-peak of expiratory flow (tPEF), as indirect measures of spinal motor network activity, were assessed before and after the intervention.

resultsIn the COVID-19 group, the scTS intervention led to significantly increased PIF (

conclusionsIn post-COVID-19 patients, scTS facilitates excitation of both inspiratory and expiratory spinal neural networks leading to an immediate improvement of respiratory functional performance. This neuromodulation approach could be utilized in rehabilitation programs for patients with COVID-19 respiratory deficits.

Indexed as

COVID-19neuromodulationrehabilitationrespirationspinal cord stimulation

Identifiers

PMID37511940
PMCPMC10381407
OpenAlexW4384557604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.