Evidence map›Paper›PMID 37511803›Full record

ArticleLife (Basel, Switzerland)2023

Methoxylated Cinnamic Esters with Antiproliferative and Antimetastatic Effects on Human Lung Adenocarcinoma Cells.

João Graciano Sampaio, Carolina Girotto Pressete, Adilson Vidal Costa, Felipe Terra Martins, Graziela Domingues de Almeida Lima, Marisa Ionta, Róbson Ricardo Teixeira

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

João Graciano SampaioGrupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil.
Carolina Girotto PressetePrograma de Pós-Graduação em Biociências Aplicadas à Saúde, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas 37130-000, MG, Brazil.
Adilson Vidal CostaDepartamento de Química e Física, Universidade Federal do Espírito Santo, Guararema, Alegre 29500-000, ES, Brazil.ORCID 0000-0002-7968-8586
Felipe Terra MartinsDepartamento de Química, Universidade Federal de Goiás, Goiânia 74690-900, GO, Brazil.
Graziela Domingues de Almeida LimaPrograma de Pós-Graduação em Biociências Aplicadas à Saúde, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas 37130-000, MG, Brazil.
Marisa IontaPrograma de Pós-Graduação em Biociências Aplicadas à Saúde, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas 37130-000, MG, Brazil.ORCID 0000-0001-8796-1426
Róbson Ricardo TeixeiraGrupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil.ORCID 0000-0003-3181-1108

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02036-21National Council for Scientific and Technological Development 431330/2018-2
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer mortality worldwide, and malignant melanomas are highly lethal owing to their elevated metastatic potential. Despite improvements in therapeutic approaches, cancer treatments are not completely effective. Thus, new drug candidates are continuously sought. We synthesized mono- and di-methoxylated cinnamic acid esters and investigated their antitumor potential. A cell viability assay was performed to identify promising substances against A549 (non-small-cell lung cancer) and SK-MEL-147 (melanoma) cells. (

Indexed as

antiproliferative activitymonomethoxylated cinnamic acid derivativesnon-small-cell lung cancer

Identifiers

PMID37511803
PMCPMC10381754

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.