Evidence map›Paper›PMID 37511642›Full record

ReviewJournal of personalized medicine2023

Creeping Fat in Crohn's Disease-Surgical, Histological, and Radiological Approaches.

Ioanna Aggeletopoulou, Efthymios P Tsounis, Athanasia Mouzaki, Christos Triantos

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Stricturing Diseases of the Gastrointestinal Tract-Current Clinical Practice.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Can Creeping Fat Be a Prognostic Factor in Crohn's Disease?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Gut microbiota in Crohn's disease pathogenesis.World journal of gastroenterology · 2025
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ioanna AggeletopoulouDivision of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0003-4489-1485
Efthymios P TsounisDivision of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0003-2797-5070
Athanasia MouzakiDivision of Hematology, Department of Internal Medicine, Medical School, University of Patras, 26504 Patras, Greece.ORCID 0000-0001-5548-7002
Christos TriantosDivision of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0003-3094-8209
General University Hospital of Patras · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the course of Crohn's disease, the response of mesenteric adipose tissue to the production of inflammatory mediators and bacterial invasion through the intestinal mucosa results in the formation of creeping fat. Creeping fat describes the arresting finger-like projections that surround the inflamed bowel. In this review, the microscopic and macroscopic features of creeping fat and histological evidence for the importance of this tissue are discussed. Moreover, the most recent insights into the radiological assessment of creeping fat in patients with Crohn's disease are reported. Advances in imaging techniques have revolutionized the possibility of visualization and quantification of adipose tissue depots with excellent accuracy. Visceral fat has been significantly correlated with various Crohn's-disease-related outcomes. Despite the difficulties in distinguishing physiologic perienteric fat from creeping fat, the growing interest in fat-wrapping in Crohn's disease has rejuvenated radiologic research. With regard to the noninvasive fat-wrapping assessment, a novel CT enterography-based mesenteric creeping fat index has been developed for the mitigation of the confounding effect of normal retroperitoneal and perienteric adipose tissue. Research on machine learning algorithms and computational radiomics in conjunction with mechanistic studies may be the key for the elucidation of the complex role of creeping fat in Crohn's disease.

Indexed as

adipose tissueartificial intelligencecreeping fatCrohn’s diseasefat wrappinghistological characteristicsimaging datamesenteric adipose tissue

Identifiers

PMID37511642
PMCPMC10381426
OpenAlexW4381617355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.