Evidence map›Paper›PMID 37511603›Full record

ArticleInternational journal of molecular sciences2023

Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease.

Máté Fehér, Zsombor Márton, Ákos Szabó, János Kocsa, Viktória Kormos, Ágnes Hunyady, László Ákos Kovács, Balázs Ujvári, Gergely Berta, József Farkas and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Máté FehérDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Zsombor MártonDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Ákos SzabóDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
János KocsaDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Viktória KormosDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.ORCID 0000-0002-3360-2425
Ágnes HunyadyDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
László Ákos KovácsDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Balázs UjváriDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Gergely BertaDepartment of Medical Biology and Central Electron Microscopic Laboratory, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
József FarkasDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.ORCID 0000-0003-4940-3014
Nóra FürediDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Tamás GasznerDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Bence PytelDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.ORCID 0009-0008-9903-5006
Dóra ReglődiDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Balázs GasznerDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.ORCID 0000-0003-2830-2732
University of Pecs · HUSomogy Megyei Kaposi Mór Oktató Kórház · HU

Funding

Hungarian Academy of Sciences BO/00750/22/5Hungarian Scientific Research Fund ELKH-TKI14016Hungarian Scientific Research Fund NAP 3.0Hungarian Scientific Research Fund NKFIH FK124188Hungarian Scientific Research Fund NKFIH K135457Ministry for Innovation and Technology TKP2021-EGA-16Ministry for Innovation and Technology ÚNKP-20-4-II-PTE-547Ministry for Innovation and Technology ÚNKP-22-5-PTE-1740University of Pecs KA-2020-03University of Pecs KA-2022-29
6 · The paper itself

Abstract

Numerous in vitro and in vivo models of Parkinson's disease (PD) demonstrate that pituitary adenylate cyclase-activating polypeptide (PACAP) conveys its strong neuroprotective actions mainly via its specific PAC1 receptor (PAC1R) in models of PD. We recently described the decrease in PAC1R protein content in the basal ganglia of macaques in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD that was partially reversed by levodopa therapy. In this work, we tested whether these observations occur also in the rotenone model of PD in the rat. The rotarod test revealed motor skill deterioration upon rotenone administration, which was reversed by benserazide/levodopa (B/L) treatment. The sucrose preference test suggested increased depression level while the open field test showed increased anxiety in rats rendered parkinsonian, regardless of the received B/L therapy. Reduced dopaminergic cell count in the substantia nigra pars compacta (SNpc) diminished the dopaminergic fiber density in the caudate-putamen (CPu) and decreased the peptidergic cell count in the centrally projecting Edinger-Westphal nucleus (EWcp), supporting the efficacy of rotenone treatment. RNAscope in situ hybridization revealed decreased PACAP mRNA (

Indexed as

Edinger-Westphal NucleusParkinson DiseaseAnimalsBasal GangliaDopamineDown-RegulationLevodopaPituitary Adenylate Cyclase-Activating PolypeptideRatsReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IRotenoneSubstantia NigraAdcyap1 protein, ratAdcyap1r1 protein, ratDopamineLevodopaPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IRotenonecaudate-putamencortexentopeduncular nucleusglobus pallidusnon-motor symptoms of Parkinson’s diseaseratrotarod

Identifiers

PMID37511603
PMCPMC10380602
OpenAlexW4385241882

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.