Evidence map›Paper›PMID 37511545›Full record

ArticleInternational journal of molecular sciences2023

Novel Antimicrobial Peptides from Saline Environments Active against

Jakub Lach, Magdalena Krupińska, Aleksandra Mikołajczyk, Dominik Strapagiel, Paweł Stączek, Agnieszka Matera-Witkiewicz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Antibacterial Activities of Predicted AMP inInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Halocin H4 is activated through cleavage by halolysin HlyR4.Applied and environmental microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jakub LachDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0002-4284-6827
Magdalena KrupińskaScreening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Aleksandra MikołajczykScreening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Dominik StrapagielBiobank Lab, Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-235 Lodz, Poland.ORCID 0000-0001-9752-4270
Paweł StączekDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0003-4416-8289
Agnieszka Matera-WitkiewiczScreening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0002-1064-1237
University of Łódź · PLWroclaw Medical University · PL

Funding

National Centre for Research and Development POWR.03.02.00-00-I033/16-00University of Łódź WBIOŚ B2111000000038.01Wroclaw Medical University SUBZ.D250.23.035
6 · The paper itself

Abstract

Microorganisms inhabiting saline environments have been known for decades as producers of many valuable bioproducts. These substances include antimicrobial peptides (AMPs), the most recognizable of which are halocins produced by halophilic Archaea. As agents with a different modes of action from that of most conventionally used antibiotics, usually associated with an increase in the permeability of the cell membrane as a result of a formation of channels and pores, AMPs are a currently promising object of research focused on the investigation of antibiotics with non-standard modes of action. The aim of this study was to investigate antimicrobial activity against multidrug-resistant human pathogens of three peptides, which were synthetised based on sequences identified in metagenomes from saline environments. The investigations were performed against

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial PeptidesHumansMicrobial Sensitivity TestsPeptidesAnti-Bacterial AgentsAntimicrobial PeptidesPeptidesantimicrobial peptideshalophilesmetagenomicsmolecular dockingsequencing

Identifiers

PMID37511545
PMCPMC10380286
OpenAlexW4385224725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.