Evidence map›Paper›PMID 37511490›Full record

ArticleInternational journal of molecular sciences2023

TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma.

Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Niranjana AminNational Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Herui WangNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2293-4819
Qi SongNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Manju BhaskarTranslational Neuroscience Center, National Institutes of Health, Bethesda, MD 20892, USA.
Sharda Prasad YadavVaxess Technologies, Woburn, MA 02139, USA.
Mark R GilbertNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Harish PantNational Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Emeline TabouretNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4031-2178
Zhengping ZhuangNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · USCentre National de la Recherche Scientifique · FRVaxess Technologies (United States) · US

Funding

Intramural Research Program of the NIH, National Cancer Institute (NCI) N/AIntramural Research Program of the NIH, National Institute of Neurological Disorders and Stroke (NINDS) N/A
6 · The paper itself

Abstract

Colorectal carcinoma (CRC) is a prevalent cancer worldwide with a high mortality rate. Evidence suggests that increased expression of Cyclin-dependent kinase 5 (

Indexed as

Colorectal NeoplasmsCyclin-Dependent Kinase 5AnimalsApoptosisCell Line, TumorG2 Phase Cell Cycle CheckpointsHumansIrinotecanMiceReactive Oxygen SpeciesCyclin-Dependent Kinase 5IrinotecanReactive Oxygen SpeciesCDK5colorectal carcinoma (CRC)DNA damageTP5xenograft mouse model

Identifiers

PMID37511490
PMCPMC10380212
OpenAlexW4385226918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.