Evidence map›Paper›PMID 37511462›Full record

ArticleInternational journal of molecular sciences2023

Thymocyte Development of Humanized Mice Is Promoted by Interactions with Human-Derived Antigen Presenting Cells upon Immunization.

Takataro Fukuhara, Yoshihiro Ueda, Sung-Il Lee, Tokifumi Odaka, Shinsuke Nakajima, Jun-Ichi Fujisawa, Kazu Okuma, Makoto Naganuma, Kazuichi Okazaki, Naoyuki Kondo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Takataro FukuharaDivision of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Yoshihiro UedaDepartment of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.ORCID 0000-0002-1112-9841
Sung-Il LeeDepartment of Model Animal, Institute of Biomedical Science, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Tokifumi OdakaDepartment of Microbiology, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Shinsuke NakajimaDepartment of Microbiology, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Jun-Ichi FujisawaDepartment of Microbiology, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Kazu OkumaDepartment of Microbiology, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Makoto NaganumaDivision of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Kazuichi OkazakiDivision of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Naoyuki KondoDepartment of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.ORCID 0000-0002-6624-5989
Yuji KamiokaDepartment of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.ORCID 0000-0002-7532-1787
Mitsuru MatsumotoDivision of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Kuramoto 770-8503, Tokushima, Japan.
Tatsuo KinashiDepartment of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Kansai Medical University · JPTokushima University · JP

Funding

Japan Society for the Promotion of Science 20K17036Kansai Medical University a "Private University Research Branding Project on intractable immune and allergic diseases" grant from Kansai Medical UniversityTokushima University a cooperative research grant from the Institute for Enzyme Research Joint Usage/Research Center
6 · The paper itself

Abstract

Immune responses in humanized mice are generally inefficient without co-transplantation of human thymus or HLA transgenes. Previously, we generated humanized mice via the intra-bone marrow injection of CD133+ cord blood cells into irradiated adult immunodeficient mice (IBMI-huNSG mice), which could mount functional immune responses against HTLV-1, although the underlying mechanisms were still unknown. Here, we investigated thymocyte development in IBMI-huNSG mice, focusing on the roles of human and mouse MHC restriction. IBMI-huNSG mice had normal developmental profiles but aberrant thymic structures. Surprisingly, the thymic medulla-like regions expanded after immunization due to enhanced thymocyte expansion in association with the increase in HLA-DR+ cells, including CD205

Indexed as

Leukocytes, MononuclearThymocytesAnimalsAntigen-Presenting CellsHLA-DR AntigensHumansImmunizationMiceThymus GlandHLA-DR Antigensdendritic cellshumanized miceimmunizationMHCthymus development

Identifiers

PMID37511462
PMCPMC10380196
OpenAlexW4385070100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.