Evidence map›Paper›PMID 37511424›Full record

ArticleInternational journal of molecular sciences2023

Evaluation of Novel Enhancer Compounds in Gentamicin-Mediated Readthrough of Nonsense Mutations in Rett Syndrome.

Keit Men Wong, Eike Wegener, Alireza Baradaran-Heravi, Brenda Huppke, Jutta Gärtner, Peter Huppke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Keit Men WongDepartment of Neuropediatrics, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0002-5449-6318
Eike WegenerDepartment of Pediatrics and Adolescent Medicine, Division of Neuropediatrics, Pediatric Neurology University Medical Center Göttingen, Georg August University Göttingen, 37075 Göttingen, Germany.
Alireza Baradaran-HeraviDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver BC V6T 1Z3, Canada.
Brenda HuppkeDepartment of Neuropediatrics, Jena University Hospital, 07747 Jena, Germany.
Jutta GärtnerDepartment of Pediatrics and Adolescent Medicine, Division of Neuropediatrics, Pediatric Neurology University Medical Center Göttingen, Georg August University Göttingen, 37075 Göttingen, Germany.ORCID 0000-0003-4108-7109
Peter HuppkeDepartment of Neuropediatrics, Jena University Hospital, 07747 Jena, Germany.
Jena University Hospital · DEUniversitätsmedizin Göttingen · DEUniversity of British Columbia · CA

Funding

Deutsche Forschungsgemeinschaft GA354/14-1, GA354/16-1, HU 941/2-5, TRR274, EXC2067
6 · The paper itself

Abstract

Rett syndrome (RTT), a severe X-linked neurodevelopmental disorder, is primarily caused by mutations in the methyl CpG binding protein 2 gene (

Indexed as

Rett SyndromeAnimalsCodon, NonsenseGentamicinsHeLa CellsHumansMethyl-CpG-Binding Protein 2MiceMutationCodon, NonsenseGentamicinsMethyl-CpG-Binding Protein 2aminoglycosidesmethyl-CpG-binding proteinnonsense suppression therapyreadthroughRett syndrome

Identifiers

PMID37511424
PMCPMC10380790
OpenAlexW4384828683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.