Evidence map›Paper›PMID 37511398›Full record

ReviewInternational journal of molecular sciences2023

Heterodimers Are an Integral Component of Chemokine Signaling Repertoire.

Kimia Kaffashi, Didier Dréau, Irina V Nesmelova

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kimia KaffashiDepartment of Biological Sciences, University of North Carolina, Charlotte, NC 28223, USA.
Didier DréauDepartment of Biological Sciences, University of North Carolina, Charlotte, NC 28223, USA.ORCID 0000-0002-7094-650X
Irina V NesmelovaDepartment of Physics and Optical Sciences, University of North Carolina, Charlotte, NC 28223, USA.

Funding

University of North Carolina at Charlotte FRG
6 · The paper itself

Abstract

Chemokines are a family of signaling proteins that play a crucial role in cell-cell communication, cell migration, and cell trafficking, particularly leukocytes, under both normal and pathological conditions. The oligomerization state of chemokines influences their biological activity. The heterooligomerization occurs when multiple chemokines spatially and temporally co-localize, and it can significantly affect cellular responses. Recently, obligate heterodimers have emerged as tools to investigate the activities and molecular mechanisms of chemokine heterodimers, providing valuable insights into their functional roles. This review focuses on the latest progress in understanding the roles of chemokine heterodimers and their contribution to the functioning of the chemokine network.

Indexed as

ChemokinesLeukocytesCell MovementChemokinesbindingchemokinechemokine receptorglycosaminoglycanheterodimerheteromeroligomerizationsignalingstructuresynergy

Identifiers

PMID37511398
PMCPMC10380872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.