Evidence map›Paper›PMID 37511312›Full record

ArticleInternational journal of molecular sciences2023

Effects of Probiotics on Colitis-Induced Exacerbation of Alzheimer's Disease in

Bijayani Sahu, Lauren M Johnson, Mona Sohrabi, Anastasia A Usatii, Rachel M J Craig, Joshua B Kaelberer, Sathiya Priya Chandrasekaran, Harpreet Kaur, Suba Nookala, Colin K Combs

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bijayani SahuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Lauren M JohnsonDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Mona SohrabiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Anastasia A UsatiiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Rachel M J CraigDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Joshua B KaelbererDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Sathiya Priya ChandrasekaranDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Harpreet KaurThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Suba NookalaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Colin K CombsDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
University of North Dakota · USJackson Laboratory · US

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
Communicating Intestinal Inflammation to the Brain in Alzheimer's DiseaseRF1AG069378 · NIA · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2020 to 2022
$1.6M
Brain-Gut Communication in Alzheimer's DiseaseR01AG048993 · NIA · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2015 to 2019
$1.4M
NIA NIH HHS R01 AG048993NIA NIH HHS RF1 AG069378NIGMS NIH HHS P20 GM113123NIGMS NIH HHS U54 GM128729NIH HHS NIH RF1AG069378, NIH R01AG048993, NIH P20GM113123, NIH U54GM128729
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by progressive cognitive decline and is a leading cause of death in the United States. Neuroinflammation has been implicated in the progression of AD, and several recent studies suggest that peripheral immune dysfunction may influence the disease. Continuing evidence indicates that intestinal dysbiosis is an attribute of AD, and inflammatory bowel disease (IBD) has been shown to aggravate cognitive impairment. Previously, we separately demonstrated that an IBD-like condition exacerbates AD-related changes in the brains of the

Indexed as

Alzheimer DiseaseColitisInflammatory Bowel DiseasesMobile ApplicationsProbioticsAmyloid beta-PeptidesAnimalsCytokinesDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesCytokinesAlzheimer’samyloidcolitisintestine

Identifiers

PMID37511312
PMCPMC10381012
OpenAlexW4384694821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.