Evidence map›Paper›PMID 37511242›Full record

ArticleInternational journal of molecular sciences2023

Human Mutated

Elena Cannone, Valeria Guglielmi, Giulia Marchetto, Chiara Tobia, Barbara Gnutti, Barbara Cisterna, Paola Tonin, Alessandro Barbon, Gaetano Vattemi, Marco Schiavone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elena CannoneDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7595-8625
Valeria GuglielmiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, 37134 Verona, Italy.
Giulia MarchettoDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-2447-7191
Chiara TobiaDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-0985-7356
Barbara GnuttiDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-8583-2583
Barbara CisternaDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9314-4377
Paola ToninDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, 37134 Verona, Italy.
Alessandro BarbonDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-1127-7764
Gaetano VattemiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-3412-8339
Marco SchiavoneDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-8566-5559
University of Brescia · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myofibrillar myopathies (MFMs) are a group of hereditary neuromuscular disorders sharing common histological features, such as myofibrillar derangement, Z-disk disintegration, and the accumulation of degradation products into protein aggregates. They are caused by mutations in several genes that encode either structural proteins or molecular chaperones. Nevertheless, the mechanisms by which mutated genes result in protein aggregation are still unknown. To unveil the role of myotilin and αB-crystallin in the pathogenesis of MFM, we injected zebrafish fertilized eggs at the one-cell stage with expression plasmids harboring cDNA sequences of human wildtype or mutated

Indexed as

CrystallinsMyopathies, Structural, Congenitalalpha-Crystallin B ChainAnimalsHumansMicrofilament ProteinsMuscle, SkeletalMutationMyofibrilsProtein AggregatesZebrafishalpha-Crystallin B ChainCRYAB protein, humanCrystallinsMicrofilament ProteinsMYOT protein, humanProtein Aggregatesmyofibrillar myopathymyotilinzebrafish modelαB-crystallin

Identifiers

PMID37511242
PMCPMC10380269
OpenAlexW4384526021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.