Evidence map›Paper›PMID 37511241›Full record

ReviewInternational journal of molecular sciences2023

Physico-Chemical Approaches to Investigate Surface Hydroxyls as Determinants of Molecular Initiating Events in Oxide Particle Toxicity.

Cristina Pavan, Rosangela Santalucia, Guillermo Escolano-Casado, Piero Ugliengo, Lorenzo Mino, Francesco Turci

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Revealing SOPhysical chemistry chemical physics : PCCP · 2025
    Article
  6. Resolving the Nanostructure of Carbon Nitride-Supported Single-Atom Catalysts.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Cristina PavanDepartment of Chemistry, University of Torino, Via Giuria 7, 10125 Torino, Italy.ORCID 0000-0003-3786-426X
Rosangela SantaluciaDepartment of Chemistry, University of Torino, Via Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-8775-5697
Guillermo Escolano-CasadoDepartment of Chemistry, University of Torino, Via Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-1996-1253
Piero UgliengoDepartment of Chemistry, University of Torino, Via Giuria 7, 10125 Torino, Italy.ORCID 0000-0001-8886-9832
Lorenzo MinoDepartment of Chemistry, University of Torino, Via Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-9882-8361
Francesco TurciDepartment of Chemistry, University of Torino, Via Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-5806-829X
University of Turin · IT

Funding

European Association of Industrial Silica Producers "Surface Silanols as Key Descriptor of the Silica Hazard"
6 · The paper itself

Abstract

The study of molecular recognition patterns is crucial for understanding the interactions between inorganic (nano)particles and biomolecules. In this review we focus on hydroxyls (OH) exposed at the surface of oxide particles (OxPs) which can play a key role in molecular initiating events leading to OxPs toxicity. We discuss here the main analytical methods available to characterize surface OH from a quantitative and qualitative point of view, covering thermogravimetry, titration, ζ potential measurements, and spectroscopic approaches (NMR, XPS). The importance of modelling techniques (MD, DFT) for an atomistic description of the interactions between membranes/proteins and OxPs surfaces is also discussed. From this background, we distilled a new approach methodology (NAM) based on the combination of IR spectroscopy and bioanalytical assays to investigate the molecular interactions of OxPs with biomolecules and membranes. This NAM has been already successfully applied to SiO

Indexed as

OxidesSilicon DioxideOxidesSilicon Dioxideadsorptionmetal oxide nanoparticlesmolecular interactionmolecular recognition patternnano-bio-inorganic interfacenew approach methodology (NAM)poorly soluble particlessilicasurface chemistry

Identifiers

PMID37511241
PMCPMC10380507
OpenAlexW4384557528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.