Evidence map›Paper›PMID 37511200›Full record

ArticleInternational journal of molecular sciences2023

Obesity Associated with Prediabetes Increases the Risk of Breast Cancer Development and Progression-A Study on an Obese Rat Model with Impaired Glucose Tolerance.

Prathap Reddy Kallamadi, Deepshika Esari, Utkarsh Reddy Addi, Rushendhiran Kesavan, Uday Kumar Putcha, Siddavaram Nagini, Geereddy Bhanuprakash Reddy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Prathap Reddy KallamadiICMR-National Institute of Nutrition, Hyderabad 500007, India.
Deepshika EsariICMR-National Institute of Nutrition, Hyderabad 500007, India.
Utkarsh Reddy AddiICMR-National Institute of Nutrition, Hyderabad 500007, India.
Rushendhiran KesavanUT Southwestern Medical Center, Children Research Institute, Dallas, TX 75390, USA.ORCID 0000-0002-8540-8093
Uday Kumar PutchaICMR-National Institute of Nutrition, Hyderabad 500007, India.
Siddavaram NaginiDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalinagar 608002, India.
Geereddy Bhanuprakash ReddyICMR-National Institute of Nutrition, Hyderabad 500007, India.ORCID 0000-0003-4787-3944
National Institute of Nutrition · INAnnamalai University · INThe University of Texas Southwestern Medical Center · US

Funding

Science and Engineering Research Board EMR/2016/001984
6 · The paper itself

Abstract

Patients with comorbidities of obesity and diabetes are recognized to be at high risk of breast cancer development and face worse breast cancer outcomes. Though several reports showed the reinforced link between obesity, diabetes, and prediabetes with breast cancer, the underlying molecular mechanisms are still unknown. The present study aimed to investigate the underlying molecular link between increased risks of breast cancer due to coincident diabetes or obesity using a spontaneous obese rat model with impaired glucose tolerance (WNIN/GR-Ob rat). A single dose of solubilized DMBA suspension (40 mg/kg body weight) was orally administered to the animals at the age of 60 days to induce breast tumors. The tumor incidence, latency period, tumor frequency, and tumor volume were measured. Histology, immunohistochemistry, and immunoblotting were performed to evaluate the tumor morphology and expression levels of signal molecules. The development of mammary tumors in GR-Ob rats was characterized by early onset and shorter latency periods compared to control lean rats. While 62% of obese rats developed breast tumors, tumor development in lean rats was only 21%. Overexpression of ER, PR, Ki67, and p53 markers was observed in tumor tissues of obese rats in comparison with lean rats. The levels of the hallmarks of cell proliferation and angiogenesis involved in IGF-1/PI3K/Akt/GSK3β/β-catenin signaling pathway molecules were upregulated in obese rat breast tumors compared to lean rats. Furthermore, obesity with prediabetes is associated with changes in IGF-1 signaling and acts on PI3K/Akt/GSK3β/β-catenin signaling, which results in rapid cell proliferation and development of breast tumors in obese rats than the lean rats. These results indicate that tumor onset and development were faster in spontaneous obese rat models with impaired glucose tolerance than in their lean counterparts.

Indexed as

Glucose IntoleranceNeoplasmsPrediabetic StateAnimalsbeta CateninGlycogen Synthase Kinase 3 betaInsulin-Like Growth Factor IObesityPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsbeta CateninGlycogen Synthase Kinase 3 betaInsulin-Like Growth Factor IPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktbreast cancerDMBAinsulin signalingmetabolic syndromeobese rat modelobesityPI3K/Akt

Identifiers

PMID37511200
PMCPMC10380482
OpenAlexW4384298197

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.