Evidence map›Paper›PMID 37511154›Full record

ReviewInternational journal of molecular sciences2023

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies.

Christopher A Lucchesi, Demitria M Vasilatis, Saisamkalpa Mantrala, Thenappan Chandrasekar, Maria Mudryj, Paramita M Ghosh

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christopher A LucchesiVA Northern California Health Care System, Mather, CA 95655, USA.ORCID 0000-0001-8767-7003
Demitria M VasilatisVA Northern California Health Care System, Mather, CA 95655, USA.ORCID 0000-0003-2001-6141
Saisamkalpa MantralaVA Northern California Health Care System, Mather, CA 95655, USA.
Thenappan ChandrasekarDepartment of Urological Surgery, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Maria MudryjVA Northern California Health Care System, Mather, CA 95655, USA.
Paramita M GhoshVA Northern California Health Care System, Mather, CA 95655, USA.ORCID 0000-0002-7304-2936
VA Northern California Health Care System · USUniversity of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Comparative Medical Science Training ProgramT32OD011147 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JEROEN SAEIJ, Sara Michelle Thomasy · 2012 to 2026
$5.5M
Defining the role of the androgen receptor low molecular weight isoforms in bladder cancerI01BX003458 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI MUDRYJ, MARIA · 2017 to 2020
–
BLRD VA I01 BX003458NCI NIH HHS P30 CA093373NIH HHS T32 OD011147
6 · The paper itself

Abstract

Multiple risk factors have been associated with bladder cancer. This review focuses on pesticide exposure, as it is not currently known whether agricultural products have a direct or indirect effect on bladder cancer, despite recent reports demonstrating a strong correlation. While it is known that pesticide exposure is associated with an increased risk of bladder cancer in humans and dogs, the mechanism(s) by which specific pesticides cause bladder cancer initiation or progression is unknown. In this narrative review, we discuss what is currently known about pesticide exposure and the link to bladder cancer. This review highlights multiple pathways modulated by pesticide exposure with direct links to bladder cancer oncogenesis/metastasis (MMP-2, TGF-β, STAT3) and chemoresistance (drug efflux, DNA repair, and apoptosis resistance) and potential therapeutic tactics to counter these pesticide-induced affects.

Indexed as

Antineoplastic AgentsPesticidesUrinary Bladder NeoplasmsAnimalsDogsDrug Resistance, NeoplasmHumansRisk FactorsAntineoplastic AgentsPesticidesbladder cancermetastasispesticide exposure

Identifiers

PMID37511154
PMCPMC10380322
OpenAlexW4384341245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.