Evidence map›Paper›PMID 37511119›Full record

ArticleInternational journal of molecular sciences2023

Relative Telomere Length Is Associated with the Risk of Development and Severity of the Course of Age-Related Macular Degeneration in the Russian Population.

Olga P Dmitrenko, Olga I Abramova, Nataliia S Karpova, Malik K Nurbekov, Ekaterina S Arshinova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Olga P DmitrenkoLaboratory of Regulation of Reparative Processes, Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", 125315 Moscow, Russia.ORCID 0000-0002-2067-0971
Olga I AbramovaDepartment of Ophthalmology, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation, 125993 Moscow, Russia.
Nataliia S KarpovaLaboratory of Regulation of Reparative Processes, Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", 125315 Moscow, Russia.ORCID 0000-0001-6391-4908
Malik K NurbekovLaboratory of Regulation of Reparative Processes, Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", 125315 Moscow, Russia.
Ekaterina S ArshinovaLaboratory of Regulation of Reparative Processes, Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", 125315 Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RURussian Medical Academy of Continuous Professional Education · RU

Funding

The work was carried out within the framework of the state task of the Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology" № FGFU-2022-0011: «Identification of significant bioindicators of various disorders of body fu № FGFU-2022-0011: «Identification of significant bioindicators of various disorders of body functions».
6 · The paper itself

Abstract

One of the most significant factors for age-related macular degeneration (AMD) development is considered to be aging, the processes of which are closely associated with telomere shortening. The different forms, indicators of aggressiveness, and intensities of AMD can be observed in the same age group, confirming the need to find a biomarker for early diagnosis and be capable of monitoring the progression of the pathological process. Therefore, we investigated whether the relative telomere length (RTL) has any connection with the risk of development of disease and its progression. RTL was measured using RT-PCR in 166 people, including 96 patients with AMD. RTL was significantly lower in patients with AMD. Women were more likely to develop AMD than men (odds ratio (OR) = 9.53 × 10

Indexed as

Macular DegenerationTelomereAgingBiomarkersDisease ProgressionFemaleHumansMaleRisk FactorsBiomarkersage-associated diseasesage-related macular degenerationagingbiomarker for predicting disease progressionearly diagnosis biomarkerrelative telomere length

Identifiers

PMID37511119
PMCPMC10379970
OpenAlexW4384203112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.