Evidence map›Paper›PMID 37511087›Full record

ArticleInternational journal of molecular sciences2023

Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates.

Nikolai Y Zyk, Anastasiia S Garanina, Ekaterina A Plotnikova, Anton P Ber, Ekaterina A Nimenko, Natalia S Dashkova, Anastasiia A Uspenskaia, Radik R Shafikov, Dmitry A Skvortsov, Stanislav A Petrov and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nikolai Y ZykChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.ORCID 0000-0002-5302-9160
Anastasiia S GaraninaLaboratory of Biomedical Nanomaterials, National University of Science and Technology MISIS, 4 Leninskiy pr, Moscow 119049, Russia.ORCID 0000-0003-3442-9553
Ekaterina A PlotnikovaNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2 Botkinskiy proezd, 3, Moscow 125284, Russia.ORCID 0000-0001-8711-6919
Anton P BerChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Ekaterina A NimenkoChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Natalia S DashkovaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Anastasiia A UspenskaiaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Radik R ShafikovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Dmitry A SkvortsovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Stanislav A PetrovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.ORCID 0000-0002-6000-6100
Andrey A PankratovNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2 Botkinskiy proezd, 3, Moscow 125284, Russia.
Nikolai V ZykChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.
Alexander G MajougaDmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russia.
Elena K BeloglazkinaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.ORCID 0000-0001-6796-8241
Aleksei E MachulkinChemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia.ORCID 0000-0001-7975-0346

Funding

Russian Science Foundation 22-15-00098
6 · The paper itself

Abstract

Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents.

Indexed as

Androgen AntagonistsProstatic NeoplasmsAntigens, SurfaceCell Line, TumorCytotoxinsGlutamate Carboxypeptidase IIHumansLigandsMaleProstateAndrogen AntagonistsAntigens, SurfaceCytotoxinsGlutamate Carboxypeptidase IILigandsbimodal conjugatesmonomethyl auristatin Eprostate cancerprostate-specific membrane antigentargeted drug delivery

Identifiers

PMID37511087
PMCPMC10380083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.