ArticleJournal of clinical medicine2023
Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Beyond Structural Pathology: Central Sensitization and Chronic Pain with Reference to Lumbar Disc Herniation-A Narrative Review.Brain sciences · 2026Review
- Central sensitization-related symptoms in patients undergoing lumbar spine surgery: development and internal validation of a clinical prediction rule for first-stage screening.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Central Sensitization in Spondyloarthritis: Implications for Personalized Medicine.Journal of personalized medicine · 2026Article
- Sex differences in pain-related biopsychosocial assessments in patients with axial spondyloarthritis.Arthritis research & therapy · 2026Article
- Linking central sensitization to multisystemic manifestations in hypermobile Ehlers-Danlos syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Quadratus lumborum muscle stiffness in chronic non-specific low back pain: a diagnostic accuracy study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Pain Neuroscience Education on Reducing Opioid Dependency in African American and Caucasian Populations: A Narrative Review.Journal of clinical medicine · 2025Review
- Sex-Specific Sensory Profiles Discriminate Between Sensitization at Twelve Weeks in Patients with Acute Low Back Pain: A Retrospective Study.Journal of clinical medicine · 2025Article
- Prediction of Chronic Fracture Pain in Patients with Osteoporotic Fractures Using the Japanese Short-form Central Sensitization Inventory: A Single-center Retrospective Observational Study in a Convalescent Rehabilitation Ward.Physical therapy research · 2025Article
- Article
- How to Distinguish Non-Inflammatory from Inflammatory Pain in RA?Current rheumatology reports · 2024Review
- Value of the central sensitisation inventory in patients with axial spondyloarthritis.RMD open · 2024Article
- Impact of applying different levels of threshold-based artifact correction on the processing of heart rate variability data in individuals with temporomandibular disorder.Scientific reports · 2024Observational
- Sensory Profiles Predict Symptoms of Central Sensitization in Low Back Pain: A Predictive Model Research Study.Journal of clinical medicine · 2024Article
- Does pain intensity after total knee arthroplasty depend on somatosensory functioning in knee osteoarthritis patients? A prospective cohort study.Clinical rheumatology · 2024Article
- Serum VEGF and CGRP Biomarkers: Relationships with Pain Intensity, Electric Pain, Pressure Pain Threshold, and Clinical Symptoms in Fibromyalgia-An Observational Study.International journal of molecular sciences · 2023Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central sensitization cannot be directly demonstrated in humans and thus a gold standard is missing. Therefore, we used human assumed central sensitization (HACS) when associated with humans. The central sensitization inventory (CSI) is a screening questionnaire for addressing symptoms that are associated with HACS. This cross-sectional study compared patients with chronic pain and at least one central sensitivity syndrome with healthy, pain-free controls via ROC analyses. Analyses were performed for all participants together and for each sex separately. Regression analyses were performed on patients with chronic pain with and without central sensitivity syndromes. Based on 1730 patients and 250 healthy controls, cutoff values for the CSI for the total group were established at 30 points: women: 33 points; men: 25 points. Univariate and multivariate regression analyses were used to identify possible predictors for the CSI score in 2890 patients with chronic pain. The CSI score is associated with all independent factors and has a low association with pain severity in women and a low association with pain severity, age, and body mass index in men. The newly established CSI cutoff values are lower than in previous studies and different per sex, which might be of clinical relevance in daily practice and importance in research.
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Registered trials
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