Evidence map›Paper›PMID 37510916›Full record

ArticleJournal of clinical medicine2023

Apelin-13 as a Potential Biomarker in Critical Illness.

Marin Gergics, Gréta Pham-Dobor, Csilla Kurdi, Gergely Montskó, Krisztina Mihályi, Gábor Bánfai, Péter Kanizsai, Tamás Kőszegi, Emese Mezősi, László Bajnok

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marin Gergics1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Gréta Pham-Dobor1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Csilla KurdiJános Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.
Gergely MontskóJános Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.
Krisztina MihályiDepartment of Emergency Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Gábor BánfaiDepartment of Emergency Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0003-0042-4092
Péter KanizsaiDepartment of Emergency Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0001-7896-2857
Tamás KőszegiJános Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-3910-5745
Emese Mezősi1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0001-9367-3877
László Bajnok1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
University of Pecs · HU

Funding

The research was financed by the Higher Education Institutional Excellence Program of the Min-istry of Human Capacities in Hungary, within the framework of the 2. thematic program of the University of Pécs. NA
6 · The paper itself

Abstract

backgroundThe adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients.

methodsIn this prospective observational study, 124 critically ill patients (64 men, 60 women, median age: 70 (59-78) years) were consecutively enrolled at the time of admission. All routinely available clinical and laboratory parameters were evaluated and correlated to hormonal changes.

resultsSerum apelin-13 was 1161 (617-2967) pg/mL in non-survivors vs. 2477 (800-3531) pg/mL in survivors (

conclusionsBeyond free cortisol, serum apelin-13 may also help refine prognostic predictions in the early phase of critical illness, especially in non-septic patients.

Indexed as

apelin-13copeptinCRHcritical illnessfree cortisol

Identifiers

PMID37510916
PMCPMC10381233
OpenAlexW4385068908

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.