ReviewJournal of clinical medicine2023
Aggregate Index of Systemic Inflammation (AISI), Disease Severity, and Mortality in COVID-19: A Systematic Review and Meta-Analysis.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The predictive role of early and late-stage inflammatory markers in the development of retinopathy of prematurity in discordant twins.Eye (London, England) · 2026Article
- Article
- Plasma SH Concentrations and Mortality in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis.Antioxidants (Basel, Switzerland) · 2026Article
- Inflammatory Biomarkers Following Orthopedic Surgery: Current Evidence, Clinical Applications, and Future Perspectives-A Narrative Review.Journal of clinical medicine · 2026Review
- Utility of a Combined Diagnostic and Severity Scoring System Based on Complete Blood Count and Derived Immune-Inflammatory Indicators in Children With Mycoplasma pneumoniae Pneumonia.Journal of clinical laboratory analysis · 2026Article
- Analysis of Circadian Blood Pressure Patterns and Their Clinical, Metabolic, and Structural Correlates in Newly Diagnosed Hypertensive Patients.Biomedicines · 2026Article
- Peripheral Inflammatory Biomarkers in Parkinson's Disease: Clinical Correlations and Stratification.Cellular and molecular neurobiology · 2026Article
- Trends in complete blood count and derived inflammatory indices in ICU patients undergoing percutaneous tracheostomy: a retrospective exploratory study in Italy.Anaesthesiology intensive therapy · 2026Article
- Longitudinal trajectories of hematological indices and serum metalloproteinases-2 and 9 over 1 year after moderate and severe COVID-19.Frontiers in medicine · 2026Article
- Preoperative Aggregate Index of Systemic Inflammation is Associated with 30-Day Postoperative Pneumonia After Minimally Invasive Esophagectomy for Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study.Infection and drug resistance · 2026Article
- Comparative evaluation of the aggregate index of systemic inflammation (AISI) and its modified version for early detection of central line-associated bloodstream infection: a pilot study using machine learning techniques.GMS hygiene and infection control · 2026Article
- A prealbumin-containing TyG-FPR-AISI composite for clinically significant early sepsis-associated acute kidney injury: a single-center derivation cohort study with internal validation.Frontiers in nutrition · 2026Article
- The Joint Effect of Stress Hyperglycemia Ratio and Inflammatory Burden Exacerbates Mortality Risk and Prolongs ICU Stay in Sepsis: A Combined Analysis.Infection and drug resistance · 2026Article
- Aggregate index of systemic inflammation as a new prognostic marker in patients with coronary artery disease undergoing PCI.Scientific reports · 2025Article
- Maternal Systemic Inflammation and Fetal Thymic Size in Diabetic Pregnancies: Predictive Role of Hematological Biomarkers.Journal of clinical medicine · 2025Article
- The association between the aggregate index of systemic inflammation and abdominal aortic calcification: a National health and nutrition examination survey.Journal of cardiothoracic surgery · 2025Article
- Nonlinear associations between the aggregate index of systemic inflammation and cardiovascular disease in adults: evidence from NHANES 2011-2020.BMC public health · 2025Article
- Relationship Between Systemic Immune-Inflammation Index and In-Hospital Mortality in Sepsis Combined With Chronic Obstructive Pulmonary Disease Modified by Mechanical Ventilation.The clinical respiratory journal · 2025Article
- The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury.Scientific reports · 2025Article
- AISI and MASLD: a nonlinear association in U.S. adults (NHANES 2017-2020).BMC gastroenterology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combined indices of different haematological cell types appear to be particularly promising for investigating the link between systemic inflammation and coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to assess the aggregate index of systemic inflammation (AISI), an emerging index derived from neutrophil, monocyte, platelet, and lymphocyte counts, in hospitalized COVID-19 patients with different disease severity and survival status. We searched electronic databases between the 1st of December 2019 and the 10th of June 2023 and assessed the risk of bias and the certainty of evidence. In 13 studies, severe disease/death was associated with significantly higher AISI values on admission vs. non-severe disease/survival (standard mean difference (SMD) = 0.68, 95% CI 0.38 to 0.97,
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