Evidence map›Paper›PMID 37510400›Full record

ArticleGenes2023

Genetic Ancestry Estimates within Dutch Family Units and Across Genotyping Arrays: Insights from Empirical Analysis Using Two Estimation Methods.

Jeffrey J Beck, Talitha Ahmed, Casey T Finnicum, Koos Zwinderman, Erik A Ehli, Dorret I Boomsma, Jouke Jan Hottenga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey J BeckAvera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57105, USA.ORCID 0000-0002-1152-9968
Talitha AhmedDepartment of Biological Psychology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.
Casey T FinnicumAvera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57105, USA.
Koos ZwindermanDepartment of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Erik A EhliAvera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57105, USA.ORCID 0000-0002-7865-3015
Dorret I BoomsmaAvera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57105, USA.ORCID 0000-0002-7099-7972
Jouke Jan HottengaDepartment of Biological Psychology, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Determinants of Adolescent Exercise Behavior; towards Evidence-Based InterventionR01DK092127 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2010 to 2014
$2.2M
CYCLINS AND CHEMICAL CARCINOGENESISR01CA042157 · NCI · UNIVERSITY OF TEXAS SYSTEM · PI CONTI, CLAUDIO J · 1986 to 2004
$1.2M
NCI NIH HHS R01 CA042157NIDDK NIH HHS R01 DK092127NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U24 MH068457
6 · The paper itself

Abstract

Accurate inference of genetic ancestry is crucial for population-based association studies, accounting for population heterogeneity and structure. This study analyzes genome-wide SNP data from the Netherlands Twin Register to compare genetic ancestry estimates. The focus is on the comparison of ancestry estimates between family members and individuals genotyped on multiple arrays (Affymetrix 6.0, Affymetrix Axiom, and Illumina GSA). Two conventional methods, principal component analysis and ADMIXTURE, were implemented to estimate ancestry, each serving its specific purpose, rather than for direct comparison. The results reveal that as the degree of genetic relatedness decreases, the Euclidean distances of genetic ancestry estimates between family members significantly increase (empirical

Indexed as

EthnicityGenetics, PopulationGenotypeHumansNetherlandsPopulation GroupsADMIXTUREgenetic ancestry estimationpopulation structureprincipal components analysis (PCA)within-family analysis

Identifiers

PMID37510400
PMCPMC10379078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.