Evidence map›Paper›PMID 37510309›Full record

ArticleGenes2023

APOE Gene Associated with Dementia-Related Traits, Depression, and Anxiety in the Hispanic Population.

Chun Xu, Victoria Padilla, Stephanie Lozano, Daniela Gamez, Brenda Bin Su, Xuan Wang, Gladys Maestre, Kesheng Wang

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Metabolic Reprogramming of Microglia in Neuroinflammation and Depression.International journal of molecular sciences · 2026
    Review
  4. Clinical Associations and Possible Risk Factors for Affective Neuropsychiatric Symptoms in Older Adults With and Without Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
  5. Article
  6. Article
  7. The novel estrogen receptor beta agonist EGX358 andFrontiers in aging neuroscience · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chun XuDepartment of Health and Biomedical Science, College of Health Affairs, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.ORCID 0000-0001-7893-6341
Victoria PadillaDepartment of Health and Biomedical Science, College of Health Affairs, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Stephanie LozanoDepartment of Science, Graduate College of Biochemistry and Molecular Biology, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Daniela GamezDepartment of Health and Biomedical Science, College of Health Affairs, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Brenda Bin SuDepartment of Pediatrics, Division of Immunology, Allergy, and Retrovirology, Allergy and Immunology Baylor College of Medicine, William T. Shearer Center for Human Immunobiology, Texas Children Hospital, Houston, TX 77030, USA.
Xuan WangDepartment of Information Systems, Robert C. Vackar College of Business and Entrepreneurship, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.ORCID 0000-0001-9183-3080
Gladys MaestreNeuroscience and School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Kesheng WangDepartment of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA.
The University of Texas Rio Grande Valley · USBaylor College of Medicine · USWest Virginia University · US

Funding

Integration of Socio-Spatial Data for Neighborhoods with Multi-omic profiles to Identify and Mitigate Factors Affecting Risk of ALzheimer's DiseaseDP1AG069870 · NIA · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI MAESTRE, GLADYS E. · 2020 to 2024
$3.6M
NIA NIH HHS DP1 AG069870
6 · The paper itself

Abstract

Alzheimer's disease (AD), a main cause of dementia, is commonly seen in aging populations with a strong genetic component. AD is one of the most common neurodegenerative disorders; it is a genetically and clinically heterogeneous disease. Specific demographic factors and genetic variants have been identified in non-Hispanic populations; however, limited studies have observed the Hispanic population. Therefore, we focused on investigating a known gene, APOE, associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population in our current study. A total of 1382 subjects were studied based on data collected from the Texas Alzheimer's Research and Care Consortium (TARCC,

Indexed as

Alzheimer DiseaseApolipoproteins EAnxietyDepressionHispanic or LatinoHumansPhenotypeApolipoproteins EagingAPOE genedementiademographic factorsHispanic populationneuropsychiatric disorders

Identifiers

PMID37510309
PMCPMC10379967
OpenAlexW4383552325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.