Evidence map›Paper›PMID 37510121›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Multiparametric Contrast-Enhanced Ultrasound in Early Prediction of Response to Neoadjuvant Chemotherapy and Recurrence-Free Survival in Breast Cancer.

Caifeng Wan, Liheng Zhou, Hongli Li, Lin Wang, Fenghua Li, Wenjin Yin, Yaohui Wang, Lixin Jiang, Jinsong Lu

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Caifeng WanDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Liheng ZhouDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Hongli LiDepartment of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Lin WangDepartment of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Fenghua LiDepartment of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Wenjin YinDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Yaohui WangDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Lixin JiangDepartment of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Jinsong LuDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Rd., Shanghai 200127, China.
Shanghai Jiao Tong University · CNRenji Hospital · CN

Funding

National Natural Science Foundation of China 81801697National Natural Science Foundation of China 82103695
6 · The paper itself

Abstract

We aimed to explore the value of contrast-enhanced ultrasound (CEUS) in early prediction of pathologic complete response (pCR) and recurrence-free survival (RFS) in locally advanced breast cancer (LABC) patients treated with neoadjuvant chemotherapy (NAC). LABC patients who underwent CEUS before and during NAC from March 2014 to October 2018 were included and assessed. Logistic regression analysis and the Cox proportional hazards model were used to identify independent variables associated with pCR and RFS. Among 122 women, 44 underwent pCR. Molecular subtype, peak intensity (PEAK) and change in diameter were independent predictors of pCR after one cycle of NAC (area under the receiver operating characteristic curve [AUC], 0.81; 95% CI: 0.73, 0.88); Molecular subtype, PEAK and change in time to peak (TTP) were independently associated with pCR after two cycles of NAC (AUC, 0.85; 95% CI: 0.77, 0.91). A higher clinical T (hazard ratio [HR] = 4.75; 95% CI: 1.75, 12.87;

Indexed as

breast cancercontrast-enhanced ultrasoundneoadjuvant chemotherapypathologic complete responserecurrence-free survival

Identifiers

PMID37510121
PMCPMC10378059
OpenAlexW4384298122

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.