Evidence map›Paper›PMID 37510066›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Modulation of Neurotransmitter Pathways and Associated Metabolites by Systemic Silencing of Gut Genes in

Shikha Shukla, Ankit Saxena, Sanjeev K Shukla, Aamir Nazir

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shikha ShuklaDivision of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Ankit SaxenaSophisticated Analytical Instrumentation Facility and Research Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Sanjeev K ShuklaSophisticated Analytical Instrumentation Facility and Research Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Aamir NazirDivision of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Central Drug Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut is now recognized as the "second brain" of the human body due to its integral role in neuronal health and functioning. Although we know that the gut communicates with the brain via immunological factors, microbial metabolites, and neurotransmitters, the interplay of these systems remains poorly understood. To investigate this interplay, we silenced 48 genes that are exclusively or primarily expressed in the

Indexed as

C. elegansgut genesHR-MASmetabolitesneuroprotectionneurotransmitterNMR

Identifiers

PMID37510066
PMCPMC10378590
OpenAlexW4383955355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.