Evidence map›Paper›PMID 37509832›Full record

ArticleFoods (Basel, Switzerland)2023

Chitooligosaccharide from Pacific White Shrimp Shell Chitosan Ameliorates Inflammation and Oxidative Stress via NF-κB, Erk1/2, Akt and Nrf2/HO-1 Pathways in LPS-Induced RAW264.7 Macrophage Cells.

Lalita Chotphruethipong, Pithi Chanvorachote, Ratchaneekorn Reudhabibadh, Avtar Singh, Soottawat Benjakul, Sittiruk Roytrakul, Pilaiwanwadee Hutamekalin

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Anti-Inflammatory Effect of 21Food science & nutrition · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. IPCellular & molecular biology letters · 2024
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Lalita ChotphruethipongDepartment of Food Science, Faculty of Science, Burapha University, Mueang Chonburi, Chonburi 20131, Thailand.
Pithi ChanvorachoteDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Ratchaneekorn ReudhabibadhFaculty of Science and Technology, Hatyai University, Hat Yai 90110, Thailand.
Avtar SinghInternational Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand.ORCID 0000-0002-5184-9085
Soottawat BenjakulInternational Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand.ORCID 0000-0001-9433-3671
Sittiruk RoytrakulFunctional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, Thailand.ORCID 0000-0003-3696-8390
Pilaiwanwadee HutamekalinDivision of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai 90110, Thailand.ORCID 0000-0003-2892-7003
Prince of Songkla University · THBurapha University · THChulalongkorn University · THHatyai University · THNational Science and Technology Development Agency · TH

Funding

National Science and Technology Development Agency (NSTDA), Thailand for Chair Professor Grant P-20-52297
6 · The paper itself

Abstract

Chitooligosaccharide (COS), found in both insects and marine sources, has several bioactivities, such as anti-inflammation and antioxidant activities. However, the mechanism of shrimp shell COS on retardation of inflammatory and antioxidant effects is limited. Therefore, the aim of this study is to examine the mechanism of the aforementioned activities of COS in LPS-activated RAW264.7 macrophage cells. COS significantly improved cell viability in LPS-activated cells. COS at the level of 500 µg/mL could reduce the TNF-α, NO and IL-6 generations in LPS-activated cells (

Indexed as

anti-inflammatoryantioxidantcell signaling pathwayschitooligosaccharidemacrophage cellsshrimp shell

Identifiers

PMID37509832
PMCPMC10379839
OpenAlexW4384928827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.