Evidence map›Paper›PMID 37509774›Full record

ArticleFoods (Basel, Switzerland)2023

The Effect of Long-Term Passage on Porcine SMCs' Function and the Improvement of TGF-β1 on Porcine SMCs' Secretory Function in Late Passage.

Yan-Yan Zheng, Ze-Nan Hu, Zheng Liu, Yi-Chen Jiang, Ren-Peng Guo, Shi-Jie Ding, Guang-Hong Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yan-Yan ZhengNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.
Ze-Nan HuNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.
Zheng LiuNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.
Yi-Chen JiangNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.
Ren-Peng GuoNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.
Shi-Jie DingNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.ORCID 0000-0002-5807-0103
Guang-Hong ZhouNational Center of Meat Quality and Safety Nanjing, Key Laboratory of Meat Processing and Quality Control, Key Laboratory of Meat Processing, Nanjing 210095, China.
Nanjing Agricultural University · CN

Funding

Fundamental Research Funds for the Central Universities ZJ22195005Jiangsu Key Research and Development Plan (Modern Agriculture) BE2020302Jiangsu Natural Science Foundation for Young Scientists BK20200537the National Natural Science Foundation of China for Young Scientists 32101991
6 · The paper itself

Abstract

Cultured meat is one of the meat substitutes produced through tissue engineering and other technologies. Large-scale cell culture is the key for cultured meat products to enter the market. Therefore, this study is aimed to explore the effect of long-term passage in vitro on smooth muscle cells (SMCs) and the effect of transforming growth factor-β1 (TGF-β1) on SMCs in the late passage. Multiple passages lead to the decline of the proliferation rate of SMCs in the proliferation stage and the differentiation ability in the differentiation stage. Transcriptome results showed that the ECM pathway and aging-related signaling pathways were significantly up-regulated in the late passage period. TGF-β1 did not promote SMCs of late passage proliferation at the proliferation stage but promoted the gene and protein expression of collagen as the main protein of the extracellular matrix proteins at the differentiation stage. In addition, proteomic analysis revealed that TGF-β1 promoted the expression of cell adhesion molecules which activate the Hippo signaling pathway and the HIF-1 signaling pathway and further promoted the production of collagen-containing extracellular matrix proteins. This could provide ideas for large-scale production of cultured meat products using SMCs.

Indexed as

cultured meatextracellular matrix proteinslarge-scale cultivationSMCsTGF-β1

Identifiers

PMID37509774
PMCPMC10378609
OpenAlexW4384131733

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.