Evidence map›Paper›PMID 37509697›Full record

ReviewBiomedicines2023

Has-miR-129-5p's Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases.

Adrian Boicean, Sabrina Birsan, Cristian Ichim, Ioana Boeras, Iulian Roman-Filip, Grama Blanca, Ciprian Bacila, Radu Sorin Fleaca, Horatiu Dura, Corina Roman-Filip

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  7. Progress of Exosomal LncRNAs in Pancreatic Cancer.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Adrian BoiceanFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Sabrina BirsanFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0009-0007-7368-7674
Cristian IchimFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Ioana BoerasMolecular Biology Laboratory of the Applied Ecology Research Center, Faculty of Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, Romania.ORCID 0000-0002-1952-5654
Iulian Roman-FilipDepartment of Neurology, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology, 540136 Targu Mures, Romania.
Grama BlancaFaculty of Social Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, Romania.
Ciprian BacilaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0000-0002-0029-7591
Radu Sorin FleacaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.ORCID 0000-0002-2444-9828
Horatiu DuraFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Corina Roman-FilipFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Lucian Blaga University of Sibiu · ROUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · RO

Funding

Ministerul Cercetării și Inovării contract no. 28PFE/30.12.2021. Lucian Blaga University of Sibiu
6 · The paper itself

Abstract

At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases.

Indexed as

digestive neoplasiadownregulationmiR-129-5pneurological diseases

Identifiers

PMID37509697
PMCPMC10377727
OpenAlexW4385201901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.