Evidence map›Paper›PMID 37509624›Full record

ArticleBiomedicines2023

Development of a Transparent Transgenic Zebrafish Cellular Phenotype

Surendra K Rajpurohit, Logan Ouellette, Suvarsha Sura, Chelsea Appiah, Annabelle O'Keefe, Katherine McCarthy, Umasai Kandepu, May Ye Mon, Kirk Kimmerling, Vishal Arora and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Surendra K RajpurohitGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0017-5794
Logan OuelletteGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0006-1461-8938
Suvarsha SuraGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Chelsea AppiahGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Annabelle O'KeefeGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Katherine McCarthyGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0008-2861-1424
Umasai KandepuGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
May Ye MonGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-7519-743X
Kirk KimmerlingKHG FiteBac Technology, Marietta, GA 30064, USA.
Vishal AroraDivision of Cardiology, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Bal L LokeshwarGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1763-4718
Augusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NF-κB signaling has broad effects on cell survival, tissue growth, and proliferation activities. It controls many genes that are involved in inflammation and thus is a key player in many inflammatory diseases. The elevation of NF-κB activators is associated with elevated mortality, especially in cancer and cardiovascular diseases. The zebrafish has emerged as an important model for whole-organism in vivo modeling in translational research. In vertebrates, in-vivo spatial resolution is limited due to normal opacification of skin and subdermal structure. For in vivo imaging, skin transparency by blocking the pigmentation via chemical inhibition is required and the maintenance of this transparency is vital. The

Indexed as

caspercellular phenotypeconfocal microscopyfluorescent microscopyinflammationin vivo imagingNF-kBtransgenictransparentzebrafish

Identifiers

PMID37509624
PMCPMC10377570
OpenAlexW4384342005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.