Evidence map›Paper›PMID 37509444›Full record

ArticleBiomedicines2023

Intraamygdaloid Oxytocin Increases Time Spent on Social Interaction in Valproate-Induced Autism Animal Model.

Dávid Vörös, Orsolya Kiss, Tamás Ollmann, Kitti Mintál, László Péczely, Olga Zagoracz, Erika Kertes, Veronika Kállai, Bettina Réka László, Beáta Berta and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Dávid VörösMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.ORCID 0000-0002-6250-8657
Orsolya KissMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Tamás OllmannMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Kitti MintálMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
László PéczelyMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Olga ZagoraczMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Erika KertesMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Veronika KállaiMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Bettina Réka LászlóMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Beáta BertaMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Attila TothMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
László LénárdMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
Kristóf LászlóMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, 7602 Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that affects about 1.5% of children worldwide. One of the core symptoms is impaired social interaction. Since proper treatment has not been found yet, an investigation of the exact pathophysiology of autism is essential. The valproate (VPA)-induced rat model can be an appropriate way to study autism. Oxytocin (OT) may amend some symptoms of ASD since it plays a key role in developing social relationships. In the present study, we investigated the effect of the intraamygdaloid OT on sham and intrauterine VPA-treated rats' social interaction using Crawley's social interaction test. Bilateral guide cannulae were implanted above the central nucleus of the amygdala (CeA), and intraamygdaloid microinjections were carried out before the test. Our results show that male Wistar rats prenatally exposed to VPA spent significantly less time on social interaction. Bilateral OT microinjection increased the time spent in the social zone; it also reached the level of sham-control animals. OT receptor antagonist blocked this effect of the OT but in itself did not significantly influence the behavior of the rats. Based on our results, we can establish that intraamygdaloid OT has significantly increased time spent on social interaction in the VPA-induced autism model, and its effect is receptor-specific.

Indexed as

amygdalaautismoxytocinrat modelsocial interactionvalproate

Identifiers

PMID37509444
PMCPMC10376246
OpenAlexW4382133346

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.