Evidence map›Paper›PMID 37509378›Full record

ArticleCancers2023

A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show

Preetha Aravind, Sanjay Popat, Tara D Barwick, Neil Soneji, Mark Lythgoe, Katherina B Sreter, Jingky P Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O Aboagye and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Preetha AravindDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Sanjay PopatLung Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK.ORCID 0000-0003-2087-4963
Tara D BarwickDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Neil SonejiDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Mark LythgoeDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Katherina B SreterLung Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK.
Jingky P Lozano-KuehneDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.ORCID 0000-0002-7372-0725
Mattias BergqvistBiovica International, Uppsala Science Park, 75237 Uppsala, Sweden.
Neva PatelDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Eric O AboagyeDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.ORCID 0000-0003-2276-6771
Laura M KennyDepartment of Surgery and Cancer, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Hammersmith Hospital · GBImperial College Healthcare NHS Trust · GBRoyal Marsden NHS Foundation Trust · GBBiovica (Sweden) · SE

Funding

Medical Research Council MR/N020782/1
6 · The paper itself

Abstract

Thymidylate synthase (TS) remains a major target for cancer therapy. TS inhibition elicits increases in DNA salvage pathway activity, detected as a transient compensatory "flare" in 3'-deoxy-3'-[

methodTwenty-one patients with advanced/metastatic non-small cell lung cancer (NSCLC) scheduled to receive palliative pemetrexed ± platinum-based chemotherapy underwent

resultsNineteen patients had evaluable PET scans at both time points. A total of 32% (6/19) of patients showed

conclusionsThe better radiological response and longer survival observed in patients with an

Indexed as

18F-FLTNSCLCpemetrexedPETthymidine kinase

Identifiers

PMID37509378
PMCPMC10377924
OpenAlexW4385202201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.