Evidence map›Paper›PMID 37509263›Full record

ReviewCancers2023

The Multiple Faces of the MRN Complex: Roles in Medulloblastoma and Beyond.

Marialaura Petroni, Veronica La Monica, Francesca Fabretti, Mariaconcetta Augusto, Damiana Battaglini, Francesca Polonara, Stefano Di Giulio, Giuseppe Giannini

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marialaura PetroniDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.ORCID 0000-0002-6021-1657
Veronica La MonicaDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.ORCID 0000-0002-7149-3725
Francesca FabrettiDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.
Mariaconcetta AugustoDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.
Damiana BattagliniDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.
Francesca PolonaraDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.
Stefano Di GiulioDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.
Giuseppe GianniniDepartment of Molecular Medicine, University La Sapienza, 00161 Rome, Italy.ORCID 0000-0003-0299-4056
Sapienza University of Rome · ITIstituto Pasteur · ITItalian Institute of Technology · IT

Funding

Associazione Italiana per la ricerca sul cancro (AIRC) IG24329Fondi Ricerca Ateneo La Sapienza; PNRR-Rome Technopole FP7 PNRR-PE6-Spoke4Istituto Pasteur-Fondazione Cenci Bolognetti. Fondazione Telethon-Italy GGP20135Italian Ministry of Education-Universities and Research- Dipartimenti di Eccellenza L. 232/2016
6 · The paper itself

Abstract

Hypomorphic mutations in MRN complex genes are frequently found in cancer, supporting their role as oncosuppressors. However, unlike canonical oncosuppressors, MRN proteins are often overexpressed in tumor tissues, where they actively work to counteract DSBs induced by both oncogene-dependent RS and radio-chemotherapy. Moreover, at the same time,

Indexed as

DDRhaploinsufficiencyMRN complexp53RSRsynthetic lethalitytarget therapy

Identifiers

PMID37509263
PMCPMC10377613
OpenAlexW4384341620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.