Evidence map›Paper›PMID 37509209›Full record

ReviewCancers2023

Venous Thromboembolism and Primary Thromboprophylaxis in Perioperative Pancreatic Cancer Care.

R A L Willems, N Michiels, V R Lanting, S Bouwense, B L J van den Broek, M Graus, F A Klok, B Groot Koerkamp, B de Laat, M Roest and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. High IntratumoralInternational journal of molecular sciences · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Venous thromboembolism following surgery for pancreatic neuroendocrine neoplasms.Research and practice in thrombosis and haemostasis · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Pancreatic Cancer and Venous Thromboembolism.International journal of molecular sciences · 2024
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

R A L WillemsDepartment of Functional Coagulation, Synapse Research Institute, 6217 KD Maastricht, The Netherlands.
N MichielsDepartment of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
V R LantingDepartment of Internal Medicine, Section Vascular Medicine, University of Amsterdam, Amsterdam UMC Location, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-8269-9473
S BouwenseDepartment of Surgery, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0002-7600-9429
B L J van den BroekDepartment of Surgery, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
M GrausDepartment of Internal Medicine, Section Medical Oncology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0002-3645-1458
F A KlokDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9961-0754
B Groot KoerkampDepartment of Surgery, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
B de LaatDepartment of Functional Coagulation, Synapse Research Institute, 6217 KD Maastricht, The Netherlands.
M RoestDepartment of Platelet Pathophysiology, Synapse Research Institute, 6217 KD Maastricht, The Netherlands.
J W WilminkCancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.
N van EsDepartment of Internal Medicine, Section Vascular Medicine, University of Amsterdam, Amsterdam UMC Location, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-5256-6346
J S D MieogDepartment of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
H Ten CateThrombosis Expert Center Maastricht, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0001-7796-4463
J de Vos-GeelenDepartment of Internal Medicine, Section Medical Oncology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
University Medical Center · USLeiden University Medical Center · NLAmsterdam University Medical Centers · NLErasmus MC · NLMaastricht University · NLSynapse (Netherlands) · NLTergooi · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have shown that patients with pancreatic ductal adenocarcinoma (PDAC) treated with neoadjuvant chemo(radio)therapy followed by surgery have an improved outcome compared to patients treated with upfront surgery. Hence, patients with PDAC are more and more frequently treated with chemotherapy in the neoadjuvant setting. PDAC patients are at a high risk of developing venous thromboembolism (VTE), which is associated with decreased survival rates. As patients with PDAC were historically offered immediate surgical resection, data on VTE incidence and associated preoperative risk factors are scarce. Current guidelines recommend primary prophylactic anticoagulation in selected groups of patients with advanced PDAC. However, recommendations for patients with (borderline) resectable PDAC treated with chemotherapy in the neoadjuvant setting are lacking. Nevertheless, the prevention of complications is crucial to maintain the best possible condition for surgery. This narrative review summarizes current literature on VTE incidence, associated risk factors, risk assessment tools, and primary thromboprophylaxis in PDAC patients treated with neoadjuvant chemo(radio)therapy.

Indexed as

anticoagulation therapycancer-associated thrombosischemotherapyneoadjuvant treatmentpancreatic ductal adenocarcinomavenous thromboembolism

Identifiers

PMID37509209
PMCPMC10376958
OpenAlexW4383817814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.