Evidence map›Paper›PMID 37509130›Full record

ArticleBiomolecules2023

Exploratory Assessment of Proteomic Network Changes in Cerebrospinal Fluid of Mild Cognitive Impairment Patients: A Pilot Study.

Aida Kamalian, Sara G Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J O'Brien, Abhay Moghekar, Michael W Lutz

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aida KamalianDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.ORCID 0000-0002-6589-9083
Sara G HoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Megha PatelDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Alexandria LewisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.ORCID 0000-0002-3812-8080
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Richard J O'BrienDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.ORCID 0000-0001-9464-1551
Michael W LutzDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-8809-5574
Johns Hopkins University · USDuke University · US

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Mei Cheng Wang · 2014 to 2026
$51.5M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
NIA NIH HHS P30 AG066507NIA NIH HHS P30-AG066507NIA NIH HHS U19-AG033655
6 · The paper itself

Abstract

(1) Background: Despite the existence of well-established, CSF-based biomarkers such as amyloid-β and phosphorylated-tau, the pathways involved in the pathophysiology of Alzheimer's disease (AD) remain an active area of research. (2) Methods: We measured 3072 proteins in CSF samples of AD-biomarker positive mild cognitive impairment (MCI) participants (

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesBiomarkersHumansNerve Tissue ProteinsPeptide FragmentsPilot ProjectsProteomicstau ProteinsAmyloid beta-PeptidesBiomarkersNerve Tissue ProteinsPeptide FragmentsSCRN1 protein, humantau ProteinsAlzheimer’s diseasecerebrospinal fluidmild cognitive impairmentneuroinflammationproteomics

Identifiers

PMID37509130
PMCPMC10377001
OpenAlexW4383723690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.