Evidence map›Paper›PMID 37508992›Full record

ArticleBrain sciences2023

A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia (MAINSTREAM): A Study Protocol.

Maria Cotelli, Francesca Baglio, Rosa Manenti, Valeria Blasi, Daniela Galimberti, Elena Gobbi, Ilaria Pagnoni, Federica Rossetto, Emanuela Rotondo, Valentina Esposito and 12 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05730023 (A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05730023 narecruitingnot on this map

A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931

TypeinterventionalSponsorIRCCS Centro San Giovanni di Dio FatebenefratelliRan2023 to 2026Enrolled60ConditionsPrimary Progressive AphasiaArmsActive tDCS, individualized language training, Placebo tDCS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 1 country.

Maria CotelliNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Francesca BaglioIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, Italy.ORCID 0000-0002-6145-5274
Rosa ManentiNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-5955-2323
Valeria BlasiIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, Italy.
Daniela GalimbertiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-9284-5953
Elena GobbiNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Ilaria PagnoniNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Federica RossettoIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, Italy.
Emanuela RotondoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-6134-9407
Valentina EspositoDementia Research Center, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Roberto De IccoDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-9415-4948
Carla GiudiceDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.
Cristina TassorelliDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.
Eleonora CatricalàICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, 27100 Pavia, Italy.
Giulia PeriniDementia Research Center, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-9539-5150
Cristina AlaimoNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Elena CampanaNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Luisa BenussiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-2836-8141
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-7691-1957
Giuliano BinettiMAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Tiziana CarandiniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Stefano Francesco CappaDementia Research Center, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0003-1003-3925
Centro San Giovanni di Dio Fatebenefratelli · ITDon Carlo Gnocchi Foundation · ITUniversity of Pavia · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituto Universitario di Studi Superiori di Pavia · ITUniversity of Milan · IT

Funding

Fondazione Regionale per la Ricerca Biomedica (FRRB) UNMET MEDICAL NEEDS - Regione Lombardia Project ID: 3430931
6 · The paper itself

Abstract

Primary Progressive Aphasia (PPA) is a syndrome due to different neurodegenerative disorders selectively disrupting language functions. PPA specialist care is underdeveloped. There are very few specialists (neurologists, psychiatrists, neuropsychologists, and speech therapists) and few hospital- or community-based services dedicated to the diagnosis and continuing care of people with PPA. Currently, healthcare systems struggle to provide adequate coverage of care that is too often fragmented, uncoordinated, and unresponsive to the needs of people with PPA and their families. Recently, attention has been gained by non-invasive brain stimulation techniques that allow a personalized treatment approach, such as transcranial Direct Current Stimulation (tDCS). The MAINSTREAM trial looks forward to introducing and evaluating therapeutic innovations such as tDCS coupled with language therapy in rehabilitation settings. A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM (ID: 3430931) was registered in the clinicaltrials.gov database (identifier: NCT05730023) on 15 February 2023.

Indexed as

imaging biomarkerslanguage trainingmolecular biomarkersprimary progressive aphasiatranscranial Direct Current Stimulation

Identifiers

PMID37508992
PMCPMC10377301
OpenAlexW4384203007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.