Evidence map›Paper›PMID 37508931›Full record

ArticleBrain sciences2023

Development and In Vivo Assessment of 4-Phenyltellanyl-7-chloroquinoline-loaded Polymeric Nanocapsules in Alzheimer's Disease Models.

Ana Cláudia Funguetto-Ribeiro, Kelly Ayumi Nakama, Mikaela Peglow Pinz, Renata Leivas de Oliveira, Manoela do Sacramento, Flávia S Oliveira Pereira, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luchese, Diego Alves and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ana Cláudia Funguetto-RibeiroBiochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.ORCID 0000-0002-5573-1076
Kelly Ayumi NakamaPharmaceutical Science Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.
Mikaela Peglow PinzBiochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil.
Renata Leivas de OliveiraBiochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil.
Manoela do SacramentoClean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil.
Flávia S Oliveira PereiraBiochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.
Simone PintonBiochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.
Ethel Antunes WilhelmBiochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil.ORCID 0000-0002-2875-9962
Cristiane LucheseBiochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil.
Diego AlvesClean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil.ORCID 0000-0002-1074-0294
Daiana Silva ÁvilaBiochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.
Sandra Elisa HaasBiochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.
Universidade Federal de Pelotas · BRUniversidade Federal do Pampa · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 16/2551-0000207-0Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 16/2551-0000240-1Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 19/2551-0001970-0National Council for Scientific and Technological Development 423435/2016-7
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia in older people, and available treatments are palliative and produce undesirable side effects. The 4-phenyltellanyl-7-chloroquinoline (TQ) is an organochalcogen compound studied due to its pharmacological properties, particularly its antioxidant potential. However, TQ possesses some drawbacks such as low aqueous solubility and high toxicity, thus warranting the search for tools that improve the safety and effectiveness of new compounds. Here, we developed and investigated the biological effects of TQ-loaded polymeric nanocapsules (NCTQ) in an AD model in transgenic

Indexed as

nanoparticlesneurodegenerationneuroprotectionorganochalcogeniumtellurium

Identifiers

PMID37508931
PMCPMC10377448
OpenAlexW4382725328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.