Evidence map›Paper›PMID 37508724›Full record

ArticleChildren (Basel, Switzerland)2023

Symptom Profiles of Children and Young People 12 Months after SARS-CoV-2 Testing: A National Matched Cohort Study (The CLoCk Study).

Snehal M Pinto Pereira, Manjula D Nugawela, Kelsey McOwat, Emma Dalrymple, Laila Xu, Shamez N Ladhani, Ruth Simmons, Trudie Chalder, Olivia Swann, Tamsin Ford and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Long COVID in children and young people: then and now.Current opinion in infectious diseases · 2025
    Review
  5. Article
  6. Review
  7. "Clinical child psychology and psychiatry · 2024
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Snehal M Pinto PereiraDivision of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London WC1E 6BT, UK.ORCID 0000-0002-0876-8757
Manjula D NugawelaUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0001-5989-9530
Kelsey McOwatImmunisations and Vaccine Preventable Diseases, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK.ORCID 0000-0003-4170-1498
Emma DalrympleUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Laila XuUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Shamez N LadhaniImmunisations and Vaccine Preventable Diseases, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK.
Ruth SimmonsImmunisations and Vaccine Preventable Diseases, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK.
Trudie ChalderDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
Olivia SwannCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh EH16 4TL, UK.
Tamsin FordDepartment of Psychiatry, Hershel Smith Building Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0SZ, UK.
Isobel HeymanUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Terry SegalUniversity College London Hospitals NHS Foundation Trust, London NW1 2PG, UK.ORCID 0000-0002-4420-8810
Malcolm G SempleNIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0001-9700-0418
Natalia K RojasDivision of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London WC1E 6BT, UK.
CLoCk Consortium
Roz ShafranUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0003-2729-4961
Terence StephensonUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.

Funding

Medical Research Council MR/P020372/1
6 · The paper itself

Abstract

backgroundAlthough 99% of children and young people have been exposed to SARS-CoV-2, the long-term prevalence of post-COVID-19 symptoms in young people is unclear. The aim of this study is to describe symptom profiles 12 months after SARS-CoV-2 testing.

methodA matched cohort study of a national sample of 20,202 children and young people who took a SARS-CoV-2 PCR test between September 2020 and March 2021.

results12 months post-index-test, there was a difference in the number of symptoms reported by initial negatives who never tested positive (NN) compared to the other three groups who had at least one positive test (

conclusionsFollowing the pandemic, many young people, particularly those that have had multiple SARS-CoV-2 positive tests, experience a range of symptoms that warrant consideration and potential investigation and intervention.

Indexed as

children and young peoplelong COVIDmatched cohort studynon-hospitalisedpost-COVID-19 condition

Identifiers

PMID37508724
PMCPMC10377812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.