Evidence map›Paper›PMID 37508616›Full record

ArticleChildren (Basel, Switzerland)2023

Innovative Family-Based Genetically Informed Series of Analyses of Whole-Exome Data Supports Likely Inheritance for Grammar in Children with Specific Language Impairment.

Erin M Andres, Kathleen Kelsey Earnest, Hao Xuan, Cuncong Zhong, Mabel L Rice, Muhammad Hashim Raza

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Erin M AndresThompson Center for Autism and Neurodevelopment, University of Missouri, Columbia, MO 65201, USA.ORCID 0000-0002-3331-6728
Kathleen Kelsey EarnestLanguage Acquisition Studies Lab, University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0002-6911-4335
Hao XuanDepartment of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045, USA.
Cuncong ZhongDepartment of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0002-8777-082X
Mabel L RiceLanguage Acquisition Studies Lab, University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0002-8150-5523
Muhammad Hashim RazaChild Language Doctoral Program, University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0002-7027-5195
University of Kansas · USUniversity of Missouri · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
MORPHOSYNTACTIC ABILITIES OF SLI PROBANDS AND FAMILIESR01DC001803 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RICE, MABEL L · 1993 to 2022
$10.9M
Transgenic and Gener-Targeting CoreP20GM104936 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2012 to 2016
$10.9M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
TRAINING RESEARCHERS IN LANGUAGE IMPAIRMENTST32DC000052 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RICE, MABEL L · 1995 to 2022
$2.7M
High Throughput Sequencing System for KUMC Genomics CoreS10OD021743 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2017 to 2017
$493k
Genetic studies of specific language impairment (SLI) using consanguineousfamiliesR21DC017830 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RAZA, MUHAMMAD HASHIM · 2020 to 2022
$440k
NCI NIH HHS P30 CA036727NICHD NIH HHS U54 HD090216NIDCD NIH HHS R01 DC001803NIDCD NIH HHS R01DC001803NIDCD NIH HHS R21 DC017830NIDCD NIH HHS R21DC017830NIDCD NIH HHS T32 DC000052NIDCD NIH HHS T32DC000052NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P20 GM104936NIH HHS S10 OD021743
6 · The paper itself

Abstract

Individuals with specific language impairment (SLI) struggle with language acquisition despite average non-verbal intelligence and otherwise typical development. One SLI account focuses on grammar acquisition delay. The current study aimed to detect novel rare genetic variants associated with performance on a grammar assessment, the Test of Early Grammatical Impairment (TEGI), in English-speaking children. The TEGI was selected due to its sensitivity and specificity, consistently high heritability estimates, and its absence from all but one molecular genetic study. We performed whole exome sequencing (WES) in eight families with SLI (

Indexed as

family-basedgrammar impairmentlanguage phenotypespedigreespecific language impairmentwhole-exome sequencing

Identifiers

PMID37508616
PMCPMC10378399
OpenAlexW4382584475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.